Whole-body interdiction of lengthening of telomeres: a proposal for cancer prevention

Autor:	de Grey Ad
Rok vydání:	2005
Předmět:	Telomerase Cancer prevention food and beverages Cancer Telomere Biology medicine.disease Neoplasms Cancer cell Gene expression Cancer research medicine Humans Stem cell Gene
Zdroj:	Frontiers in Bioscience. 10:2420
ISSN:	1093-4715 1093-9946
DOI:	10.2741/1707
Popis:	The intrinsic genetic instability of cancer cells makes age-related cancers more difficult to postpone or treat than any other age-related diseases. Any treatment that a cancer can resist by activating or inactivating specific genes is unlikely to succeed over the long term, because pre-existing cancer cells with the necessary gene expression pattern will withstand the therapy and proliferate. "Whole-body Interdiction of Lengthening of Telomeres" (WILT) is a proposal to pre-empt this problem by deleting from as many of our cells as possible the genes needed for telomere elongation. Cancers lacking these genes can never reach a life-threatening stage by altering gene expression, only by acquiring new genes, which is far more unlikely. Continuously-renewing tissues can be maintained by periodic reseeding with telomere elongation-incompetent stem cells that have had their telomeres lengthened in vitro with exogenous telomerase. Here, I describe why WILT might prove to be an exceptionally powerful anti-cancer modality.
Databáze:	OpenAIRE
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