Atrial natriuretic polypeptides: structure-activity relationship in the central action--a comparison of their antidipsogenic actions
| Autor: | Kazuwa Nakao, Narito Morii, Ken'ichi Igano, Akira Sugawara, Ken Inouye, Hiroo Imura, Shozo Shiono, Goro Katsuura, Takayuki Yamada, Hiroshi Itoh, Yoshihiko Saito, Kunio Watanabe |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Water drinking business.industry General Neuroscience Angiotensin II Drinking Behavior Rats Inbred Strains Pharmacology Rats Structure-Activity Relationship Endocrinology Internal medicine cardiovascular system medicine Structure–activity relationship Animals Water intake business Inhibitory effect hormones hormone substitutes and hormone antagonists Atrial Natriuretic Factor circulatory and respiratory physiology ATRIAL NATRIURETIC POLYPEPTIDES |
| Zdroj: | Neuroscience letters. 74(1) |
| ISSN: | 0304-3940 |
| Popis: | The structure-activity relationship of atrial natriuretic polypeptides (ANPs) in the central action was investigated by examining the suppressive effects of the intracerebroventricular (i.c.v.) administration of ANPs on water intake induced by the i.c.v. injection of angiotensin II (AII) (0.1 nmol) in rats. alpha-Rat ANP (alpha-rANP), alpha-human ANP, alpha-rANP4-28 and alpha-rANP5-28 at a dose of 1.5 nmol exerted equipotent antidipsogenic actions, while alpha-rANP7-23-amide had no inhibitory effect on water drinking at this dose. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|