Influence of a Mexican Diet on the Bioavailability of Albendazole
| Autor: | S Sergio Mares, C Helgi Jung, Dinora F. González-Esquivel, A Temuchino López |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Adolescent Biological Availability Pharmacology Albendazole Toxicology law.invention Food-Drug Interactions Animal science Randomized controlled trial Pharmacokinetics law medicine Humans Anthelmintic Mexico Anthelmintics Cross-Over Studies business.industry Half-life General Medicine Plasma levels Crossover study Diet Bioavailability Area Under Curve Female business Half-Life medicine.drug |
| Zdroj: | Basic Toxicology. 97:122-124 |
| ISSN: | 1742-7843 1742-7835 |
| Popis: | With a mexican diet we have found that after a single oral dose of 800 mg of albendazole, maximum plasma levels and the area under the plasma concentration curve increased seven and eight times respectively, however the elimination rate was not altered. In order to evaluate the influence of a Mexican diet on the bioavailability of albendazole a two-way cross-over comparative study was carried out in healthy volunteers after a single oral dose of 800 mg in fasting and fed state. Sixteen healthy volunteers were included, nine men and seven women. The mean age was 24.7 years (range 18 to 33 years) and the mean weight was 62.9 kg (range 50 to 82 kg). The protocol was approved by the local ethics committee, and informed written consent was obtained from each subject after detailed explanation of the purpose and risks of the study. The volunteers did not take any other medication or alcohol for at least 15 days prior the study . The volunteers were randomly separated into two groups of 8 each. Albendazole (EskazoleTM, 400 mg) was administered in a single oral dose of 800 mg to both groups after an overnight fast. Group I received the drug with 240 ml of water and food was withheld for 4 hr after the drug was taken; then a standard lunch was allowed. Group II received albendazole after a Mexican diet which consisted of two fried eggs with tomato, onion and chili, two slices of bacon, chilaquiles (tortillas (55 g) with tomato, chili and cream (12 g) and a glass of milk (240 ml) (fat 57.1%, protein 16%, carbohydrates 26%, 963.5 kcal). Blood samples were obtained through an indwelling catheter placed in the antecubital vein at 0, 0.5, 0.75, 1.0, 1.5, 2, 2.5, 3, 4, 6 ,8 12, 24 and 48 hr after the drug administration. Samples were centrifuged and the plasma was separated and stored at a20 ae until analysis. The study was repeated in |
| Databáze: | OpenAIRE |
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