Metabolic Syndrome and Risk of Cardiovascular Events After Myocardial Infarction
| Autor: | Roberto Marchioli, Alejandro Macchia, Gian Luigi Nicolosi, RosaMaria Marfisi, Gianni Tognoni, Franco Valagussa, Carlo Schweiger, Maria Grazia Franzosi, Giacomo Levantesi, Aldo P. Maggioni, GISSI-Prevenzione Investigators, Luigi Tavazzi |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Databases Factual Heart disease Myocardial Infarction Infarction Weight Gain Risk Factors Weight loss Internal medicine Diabetes mellitus Diabetes Mellitus Prevalence medicine Humans Myocardial infarction Risk factor Proportional Hazards Models Heart Failure Metabolic Syndrome business.industry Middle Aged Prognosis medicine.disease Survival Analysis Survival Rate Endocrinology Cardiovascular Diseases Myocardial infarction complications Female Metabolic syndrome medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of the American College of Cardiology. 46:277-283 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2005.03.062 |
| Popis: | ObjectivesWe aimed to assess the prevalence and prognostic role of metabolic syndrome (METS) and diabetes in post-myocardial infarction (MI) patients.BackgroundDiabetes is a well known risk factor for patients with previous MI, but glycemic dysmetabolism develops over a protracted period of time. Scanty data are available on the role of METS in patients with previous MI.MethodsAdjusted Cox’s regression models, having diabetes, death, major cardiovascular events (CVE), and hospitalization for congestive heart failure (CHF) during follow-up as outcome events, were fitted on 11,323 patients with prior MI enrolled in the GISSI-Prevenzione Trial.ResultsAt baseline, 21% and 29% of patients had diabetes mellitus and METS, respectively. The METS patients had a significant (93%) increased risk of diabetes during follow-up. As compared with control subjects, the probability of death and CVE were higher in both METS (+29%, p = 0.002; +23%, p = 0.005) and diabetic patients (+68%, p −10%) weight reduction were associated with a significant (18% and 41%, respectively) decreased risk of diabetes. Weight gain was significantly associated with increased risk of diabetes. The risk conferred by METS and diabetes tended to be higher among women.ConclusionsIn patients with MI, METS and diabetes were highly prevalent and are associated with increased risk of death and CVE. Diabetes is also associated with increased risk of hospitalization for CHF. Weight reduction significantly decreased the risk of becoming diabetic in patients with METS. |
| Databáze: | OpenAIRE |
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