Do follicular fluid advanced glycation end products levels affect the ovarian response in unexplained infertility?
| Autor: | Kuntay Kokanalı, Cavidan Gulerman, Yasemin Tasci, Yaprak Engin-Ustun, Tuba Candar, Yasemin Yüksel, Yesim Bardakcı, Banu Seven |
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| Rok vydání: | 2021 |
| Předmět: |
Anti-Mullerian Hormone
Glycation End Products Advanced endocrine system medicine.medical_specialty endocrine system diseases Pyridones Endocrinology Diabetes and Metabolism Oocyte Retrieval 030209 endocrinology & metabolism Stimulation Fertilization in Vitro medicine.disease_cause Affect (psychology) 03 medical and health sciences 0302 clinical medicine Endocrinology Ovulation Induction Pregnancy Glycation Internal medicine Humans Medicine Prospective Studies Sperm Injections Intracytoplasmic Unexplained infertility 030219 obstetrics & reproductive medicine business.industry Ovary Pregnancy Outcome Obstetrics and Gynecology Embryo Transfer Follicular fluid female genital diseases and pregnancy complications Follicular Fluid Cross-Sectional Studies Infertility Female business Oxidative stress |
| Zdroj: | Gynecological Endocrinology. 37:802-806 |
| ISSN: | 1473-0766 0951-3590 |
| Popis: | To compare the advanced glycation end products (AGEs) levels in follicular fluid according to the different ovarian responses of women who underwent controlled ovarian stimulation due to unexplained infertility and to examine the relationship between these levels and pregnancy outcomes.Sixty-three women who underwent fresh IVF/ICSI cycles with GNRH antagonist protocol were divided into 3 groups according to the number of retrieved oocytes as suboptimal (4-9 oocytes), optimal (10-15 oocytes) and high (15 oocytes) responders. AGEs levels in follicular fluid were measured by ELISA method.AGEs levels were 6.81 ± 2.20 µg/ml, 5.30 ± 2.01 and 6.44 ± 1.43 µg/ml in suboptimal, optimal and high response group, respectively. AGEs level was significantly higher in suboptimal response group than in optimal response group. The cutoff level of 6.19 µg/ml had a sensitivity of 59.3% and a specificity of 66.7% in distinguishing the suboptimal response group from the optimal response group. However, there were no statistically significant difference between AGEs levels and clinical pregnancy and live birth rates.Increased AGEs level in follicular fluid may be associated with decreased ovarian response during controlled ovarian stimulation in unexplained infertility case, however, it does not provide information about pregnancy outcomes. |
| Databáze: | OpenAIRE |
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