Blood phosphatidyl ethanol levels as a tool to detect alcohol misuse in trauma patients
| Autor: | Victória Vendramini Müller, Jonatan de Andrade Alff, Maria Eduarda Krutzmann, Vanessa Becher da Silva, Octaviano Pereira Sagrilo, Fernando Engel Gerbase, Marina Venzon Antunes, Mariane Tegner, Rafael Linden |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcohol Glycerophospholipids Toxicology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Prospective Studies 030212 general & internal medicine Secondary prevention Ethanol business.industry Alcohol intervention food and beverages 030208 emergency & critical care medicine General Medicine Middle Aged Alcoholism Cross-Sectional Studies chemistry Emergency medicine Wounds and Injuries Blood Alcohol Content Female Phosphatidylethanol business Alcohol consumption Biomarkers |
| Zdroj: | Clinical Toxicology. 59:418-425 |
| ISSN: | 1556-9519 1556-3650 |
| DOI: | 10.1080/15563650.2020.1822531 |
| Popis: | There is a strong need for a reliable marker of harmful alcohol consumption to identify injured patients that can benefit from alcohol interventions, and blood phosphatidyl ethanol (PEth) has not previously been tested on this population. This study aims to compare the performance of blood PEth concentration, blood alcohol concentration (BAC) and the Alcohol Use Disorders Identification Test Consumption (AUDIT-C) for the screening of alcohol misuse in trauma patients. Prospective cross-sectional study of 238 adult patients presenting in the emergency department with any type of trauma. PEth concentration was determined in whole blood by high-performance liquid chromatography with tandem mass spectrometry. Consent, AUDIT-C score and demographic data were obtained. The sample consisted of majority male (67.6%), single (46.2%) and employed (66%) patients. The most common type of trauma was traffic collision (63.9%). The mean age was 41.7 years. We found a significant correlation between PEth levels with AUDIT-C score (Spearman’s r = 0.654; p < .0001). PEth had an area under the ROC curve of 0.885 to detect hazardous alcohol consumption (AUDIT-C score ≥ 6) and PEth ≥23.9 ng/mL cutoff point provided 91.2% of sensitivity and 78.4% of specificity. Twelve patients reported alcohol abstinence, but had quantifiable levels of PEth. PEth levels and AUDIT-C score had a moderate correlation in our population. PEth was useful to identify 12 cases of underreporting of alcohol consumption habits. PEth shows promising results, but more research is needed to identify the best screening tool for alcohol misuse in trauma patients. |
| Databáze: | OpenAIRE |
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