Infectious Progeny of 2009 A (H1N1) Influenza Virus Replicated in and Released from Human Neutrophils
| Autor: | Feiyuan Yu, Conghui Zhao, Zhang Zhang, Xingmu Liu, Xueling Chen, Jiang Gu, David J. Kelvin, Tao Huang |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Neutrophils viruses Receptors Cell Surface Cell Separation Chick Embryo Biology Virus Replication medicine.disease_cause Article Virus Microbiology Viral Proteins chemistry.chemical_compound Influenza A Virus H1N1 Subtype medicine Influenza A virus Animals Humans RNA Messenger Messenger RNA Multidisciplinary Virion virus diseases RNA Virus Internalization Virology Coculture Techniques In vitro Influenza A virus subtype H5N1 Sialic acid chemistry Viral replication |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep17809 |
| Popis: | Various reports have indicated that a number of viruses could infect neutrophils, but the multiplication of viruses in neutrophils was abortive. Based on our previous finding that avian influenza viral RNA and proteins were present in the nucleus of infected human neutrophils in vivo, we investigated the possibility of 2009 A (H1N1) influenza viral synthesis in infected neutrophils and possible release of infectious progeny from host cells. In this study we found that human neutrophils in vitro without detectable level of sialic acid expression could be infected by this virus strain. We also show that the infected neutrophils can not only synthesize 2009 A (H1N1) viral mRNA and proteins, but also produce infectious progeny. These findings suggest that infectious progeny of 2009 A (H1N1) influenza virus could be replicated in and released from human neutrophils with possible clinical implications. |
| Databáze: | OpenAIRE |
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