Giant extragastrointestinal stromal tumor
Autor: | Masanori Teruya, Akihiko Ito, Seiichiro Shimizu, Kaoru Kobayashi, Syunji Araki, Yosuke Nishio, Koji Morita, Masaki Kawahara, Takashi Kobayashi |
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Rok vydání: | 2003 |
Předmět: |
Pathology
medicine.medical_specialty Abdominal pain Stromal cell CD34 symbols.namesake medicine Humans Stromal tumor Aged Gastrointestinal Neoplasms Gastrointestinal tract biology business.industry CD117 General Medicine Interstitial cell of Cajal medicine.anatomical_structure symbols biology.protein Abdomen Surgery Female medicine.symptom business Tomography X-Ray Computed |
Zdroj: | American journal of surgery. 188(2) |
ISSN: | 0002-9610 |
Popis: | F t n otherwise healthy 70-year-woman was admitted to our epartment because of diffuse abdominal pain associated ith increasing abdominal girth. On physical examination, he abdomen was distended due to a huge, nontender, palable mass with no clear border. Laboratory findings and umor markers were within normal limits. A computed omography scan revealed a bulky heterogeneously enanced tumor (18 cm in size) just behind the pancreas tail. he tumor displaced the abdominal organs to the right side f the abdomen without any sign of infiltration (Fig. 1). The ass was totally excised, and the main difficulty was chieving clear margins while sparing major vessels and djacent organs. The histopathologic diagnosis was mesenhymal tumor arising from retroperitoneum in which inerlacing fasciculi of spindled cells were strongly positive or CD117 (KIT receptor; Fig. 2) and CD34, but negative or S-100 protein. The postoperative course was uneventul and the patient was free from recurrence 1 year after urgery. Gastrointestinal stromal tumors (GISTs), which were reviously classified as benign or malignant smooth muscle umors, are the most common mesenchymal tumors of he gastrointestinal tract. They express a growth factor reeptor with tyrosine kinase activity, called KIT, which is a arker of interstitial cells of Cajal and the single best arker of GISTs. These GISTs occur throughout the entire astrointestinal tract and most, if not all, either originate rom or differentiate toward interstitial cells of Cajal [1]. owever, some tumors are outside the gastrointestinal tract hat histologically closely resemble GISTs but do not really |
Databáze: | OpenAIRE |
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