First Syntheses of Melophlins P, Q, and R, and Effects of Melophlins on the Growth of Microorganisms and Tumor Cells
| Autor: | Randi Diestel, Georg Rapp, Rainer Schobert, Bernhard Biersack, Florenz Sasse, Carsten Jagusch |
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| Přispěvatelé: | Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany. |
| Rok vydání: | 2008 |
| Předmět: |
Stereochemistry
Antineoplastic Agents Bioengineering Gram-Positive Bacteria Biochemistry Inhibitory Concentration 50 Mice Solid-phase synthesis Gram-Negative Bacteria Tumor Cells Cultured medicine Animals Humans Cytotoxic T cell Molecular Biology Cisplatin biology Chemistry Kidney Carcinoma General Chemistry General Medicine Antimicrobial medicine.disease biology.organism_classification Pyrrolidinones Anti-Bacterial Agents Leukemia Molecular Medicine Antibacterial activity Bacteria medicine.drug |
| Popis: | The marine tetramic acid (=1,5-dihydro-4-hydroxy-2H-pyrrol-2-ones) derivatives melophlin P, Q, and R (1p-1r, resp.) were synthesized for the first time in only four steps. Together with the congenerous melophlins A-C and G, they were also tested for antimicrobial and cytotoxic effects. Melophlins B, C, P, Q, and R, which share a 5-Me residue, showed some antibacterial activity, mainly in Gram-positive bacteria. Melophlins B, C, and R, which have Me-branched 3-acyl side chains in common, inhibited the growth of cells of human KB-3-1 cervix carcinoma, A-498 kidney carcinoma, and U-937 leukemia with IC(50) values |
| Databáze: | OpenAIRE |
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