Granular cell tumours of the colorectum: histopathological and immunohistochemical evaluation of 30 cases

Autor:	Hye Jeong Kim, Kyung-Hwa Lee, Young Ho Kim, Sung-Sun Kim, Jong-In Na, Jae Hyuk Lee, Jong-Jae Jung, Jong Tae Park
Rok vydání:	2014
Předmět:	Adult Male Pathology medicine.medical_specialty Histology Biology Pathology and Forensic Medicine Surgical pathology Biomarkers Tumor medicine Humans Nuclear atypia Aged CD68 Lineage markers General Medicine Middle Aged Nestin Immunohistochemistry Granular Cell Tumor Synaptophysin biology.protein Female Differential diagnosis Colorectal Neoplasms
Zdroj:	Histopathology. 65:764-774
ISSN:	0309-0167
DOI:	10.1111/his.12487
Popis:	Aims Granular cell tumours (GCTs) are uncommon in the gastrointestinal tract, particularly in the colorectum. Herein, we report a series of 30 colorectal GCTs and discuss the properties of colorectal GCTs based on histopathological and immunohistochemical studies. Methods and results Searching the surgical pathology files identified 30 cases of colorectal GCTs for 2005–2013. A broad panel of antibodies including neural and macrophage markers were used for immunohistochemical evaluation. Colorectal GCTs predominantly involved the right colon and showed increased nuclear atypia including nuclear pleomorphism and nuclear spindling. All 24 cases with mucosal tumour components had infiltrative growth patterns within the mucosa. In all available cases, diffuse strong immunopositivity was observed for S100 and SOX10 of schwannian differentiation markers, as well as for CD68. Other neuronal lineage markers, including CD56, neuron-specific enolase, nestin, and synaptophysin showed consistently high expression rates. The immunohistochemical results are suggestive for a neural origin of GCTs. Conclusion Histopathological and immunohistochemical features of colorectal GCTs were delineated in this large series of 30 colorectal GCTs. Although the incidence of GCTs is relatively low, clinicians and pathologists need to be aware of GCT in the differential diagnosis.
Databáze:	OpenAIRE
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