The risk of neurodegeneration in REM sleep behavior disorder: A systematic review and meta-analysis of longitudinal studies

Autor: Enrico Giora, Marco Zucconi, Andrea Galbiati, Luigi Ferini-Strambi, Laura Verga
Přispěvatelé: Galbiati, Andrea, Verga, Laura, Giora, Enrico, Zucconi, Marco, Ferini-Strambi, Luigi
Rok vydání: 2019
Předmět:
Lewy Body Disease
Male
Pulmonary and Respiratory Medicine
Oncology
MILD COGNITIVE IMPAIRMENT
medicine.medical_specialty
Synucleinopathies
Dementia with Lewy bodies
REM sleep behavior disorder
Population
REM Sleep Behavior Disorder
Polysomnography
EARLY MARKER
RBD
03 medical and health sciences
0302 clinical medicine
PARKINSONS-DISEASE
PREDICTS EARLY TRANSITION
Physiology (medical)
Internal medicine
IMPENDING NEURODEGENERATION
Humans
Medicine
Dementia
International Classification of Sleep Disorders
Longitudinal Studies
Neurodegeneration
education
education.field_of_study
medicine.diagnostic_test
business.industry
DEMENTIA
Neurodegenerative Diseases
Parkinson Disease
medicine.disease
REM sleep without atonia
030228 respiratory system
Neurology
DELAYED EMERGENCE
Neurology (clinical)
TREATMENT OUTCOMES
FOLLOW-UP
business
Biomarkers
030217 neurology & neurosurgery
Zdroj: Sleep Medicine Reviews. 43:37-46
ISSN: 1087-0792
DOI: 10.1016/j.smrv.2018.09.008
Popis: Several studies report an association between REM Sleep Behavior Disorder (RBD) and neurodegenerative diseases, in particular synucleinopathies. Interestingly, the onset of RBD precedes the development of neurodegeneration by several years. This review and meta-analysis aims to establish the rate of conversion of RBD into neurodegenerative diseases. Longitudinal studies were searched from the PubMed, Web of Science, and SCOPUS databases. Using random-effect modeling, we performed a meta-analysis on the rate of RBD conversions into neurodegeneration. Furthermore, we fitted a Kaplan-Meier analysis and compared the differences between survival curves of different diseases with log-rank tests. The risk for developing neurodegenerative diseases was 33.5% at five years follow-up, 82.4% at 10.5 years and 96.6% at 14 years. The average conversion rate was 31.95% after a mean duration of follow-up of 4.75±2.43 years. The majority of RBD patients converted to Parkinson's Disease (43%), followed by Dementia with Lewy Bodies (25%). The estimated risk for RBD patients to develop a neurodegenerative disease over a long-term follow-up is more than 90%. Future studies should include control group for the evaluation of REM sleep without atonia as marker for neurodegeneration also in non-clinical population and target RBD as precursor of neurodegeneration to develop protective trials.
Databáze: OpenAIRE
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