Familial Anomalous B2A—Globulin
| Autor: | Stefan Mackiewicz, Kazimierz Wysocki |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Blood protein disorder
Pathology medicine.medical_specialty Blood Protein Disorders Adolescent Globulin Genetics Medical Autoimmune Diseases Immune system Internal Medicine Humans Medicine Child Blood Coagulation Immunoelectrophoresis Pathological Multiple myeloma Factor VIII biology business.industry Hemagglutination Hypergammaglobulinemia Gamma globulin Blood Coagulation Disorders medicine.disease Geriatrics Immunoglobulin G Immunology biology.protein gamma-Globulins Lymph business |
| Zdroj: | Archives of Internal Medicine. 116:351 |
| ISSN: | 0003-9926 |
| Popis: | GAMMA globulins obtained from normal persons and from patients with multiple myeloma have been well characterized. Their immunochemical differences are clearly recognized. Immunoelectrophoretic studies led to the division of these proteins into three basic groups: 6.6S, 7S globulin, β2Aand β2M-globulin.1-5Immune globulins are formed almost entirely in normal plasma cells and their precursors, or result from the metabolism of malignant plasma cells. High levels of individual immune globulins, or structurally abnormal globulins, are usually associated with malignant but immunologically competent cells. According to Waldenstrom, however, hypergammaglobulinemia may occur in benign conditions, or as a familial disease. Pathological abnormalities in lymph nodes may be absent. Changes in immune globulins may be associated with various pathological phenomena; the best known are the altered immune response and hemorrhagic disorders.6The abnormalities usually result from an anomaly in β2Mor γ7S-globulin; they are less common as a result of β2M |
| Databáze: | OpenAIRE |
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