Radiobiological effectiveness of iodouracil and the influence of atomic giant resonance
| Autor: | Roberto D. Rivarola, A. Mandal, Juan Manuel Monti, Philippe F. Weck, Lokesh C. Tribedi, Madhusree Roy Chowdhury, Chandan Bagdia |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Physics
Electron purl.org/becyt/ford/1.3 [https] BIOMOLECULES 01 natural sciences Resonance (particle physics) 010305 fluids & plasmas Ion ION-MOLECULE COLLISIONS purl.org/becyt/ford/1 [https] Dipole Giant resonance Ionization 0103 physical sciences HADRON-THERAPY IONIZATION Continuum (set theory) Atomic physics 010306 general physics Excitation IODURACIL |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| Popis: | Hadron therapy combined with nanotechnology has been proposed as an elegant alternative for cancer treatment. Internal amplification of electron emission causing radiobiological effectiveness in nanoinserted biomolecules is of prime importance and has been measured here for the iodouracil molecule. Our experiment involves the measurement of angle and energy resolved double differential cross section (DDCS) of electron emission from iodouraciil and uracil (and also water) in collisions with fast C6+ ions. The electron emission from iodouracil is substantially enhanced over that from uracil or water. The enhancement is much larger than the state-of-the-art model for Coulomb ionization based on the continuum distorted wave-eikonal initial state (CDW-EIS) approximation. The electron sensitizing factor (˜2.4) is in excellent agreement with the strand-breaking sensitizing factor (˜2.0) for metal nanoparticle embedded in a DNA. The enhancement is explained in terms of collective excitation of strongly correlated 4d electrons, known as atomic giant dipole resonance (GDR) in I atoms. The GDR contribution to the enhancement is derived, which is in excellent agreement with recent theoretical prediction, thereby providing conclusive experimental evidence of the crucial role of collective excitation in radio sensitization. Fil: Mandal, Anuvab. International Centre of Theoretical Science. Tata Institute of Fundamental Research; España Fil: Chowdhury, Madhusree Roy. International Centre of Theoretical Science. Tata Institute of Fundamental Research; España Fil: Bagdia, Chandan. International Centre of Theoretical Science. Tata Institute of Fundamental Research; España Fil: Monti, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; Argentina Fil: Rivarola, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; Argentina Fil: Weck, Philippe F.. Sandia National Laboratories; Estados Unidos Fil: Tribedi, Lokesh C.. International Centre of Theoretical Science. Tata Institute of Fundamental Research; España |
| Databáze: | OpenAIRE |
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