Detection of anti-Saccharomyces cerevisiae antibodies in Crohn's disease: is it reliable diagnostic and prognostic marker?
| Autor: | R. Sostegni, Marco Daperno, Marco Astegiano, G.C. Molinaro, F. Castellino, Giuseppe Rocca, G. Masoero, C. Rigazio, C. Zaffino, Elena Ercole, Francesca Bresso, Rodolfo Rocca, Angelo Pera |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Population Saccharomyces cerevisiae Disease Inflammatory bowel disease Serology Diagnosis Differential Crohn Disease Predictive Value of Tests medicine Humans education Crohn's disease education.field_of_study Hepatology biology business.industry Gastroenterology Inflammatory Bowel Diseases Prognosis medicine.disease Antibodies Anti-Idiotypic Predictive value of tests Immunology Linear Models biology.protein Female Differential diagnosis Antibody business Biomarkers |
| Zdroj: | Digestive and Liver Disease. 33:755-761 |
| ISSN: | 1590-8658 |
| DOI: | 10.1016/s1590-8658(01)80692-7 |
| Popis: | In the past few years, serologic markers have been proposed in inflammatory bowel disease. Anti-Saccharomyces cerevisiae antibodies showed high specificity for Crohn's disease. A prognostic role for serology has also been hypothesised.To evaluate anti-Saccharomyces cerevisiae antibody distribution in an unselected Italian inflammatory bowel disease population. To analyse whether anti-Saccharomyces cerevisiae antibody status (positive/negative) and/or anti-Saccharomyces cerevisiae antibody titres are associated with clinical variables and outcome measures in Crohn's disease patients.A series of 299 inflammatory bowel disease patients were evaluated; serum samples were taken and a short clinical history was recorded. anti-Saccharomyces cerevisiae antibodies IgG enzyme-linked immunosorbent assay Medilab (Milan, Italy) kit was used in order to determine anti-Saccharomyces cerevisiae antibody status.Sensitivity, specificity and likelihood ratio for positive test in the differential diagnosis of inflammatory bowel disease was 59%, 89%, 8.1, respectively. Clinical variables significantly associated with anti-Saccharomyces cerevisiae antibody status in logistic regression were found to be ileal location (p=0.01) and earlier age at diagnosis (p0.01). Among ileal Crohn's disease patients, there was a trend in concordance between anti-Saccharomyces cerevisiae antibody titres and higher number of surgical procedures which was not statistically significant applying more complex statistics.In an Italian inflammatory bowel disease population, anti-Saccharomyces cerevisiae antibodies status showed characteristics similar to those previously reported. Anti-Saccharomyces cerevisiae antibody positivity is associated with ileal involvement and with earlier onset of Crohn's disease. |
| Databáze: | OpenAIRE |
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