The disease stage-associated imbalance of Th1/Th2 and Th17/Treg in uterine cervical cancer patients and their recovery with the reduction of tumor burden

Autor: Zhaoyuan Niu, Zhen Wang, Yan Kong, Hua-ling Zhang, Fang Yuan, Wei Lin, Xingsheng Yang
Rok vydání: 2020
Předmět:
Adult
Oncology
medicine.medical_specialty
Cell
Uterine Cervical Neoplasms
Disease
medicine.disease_cause
Cervical intraepithelial neoplasia
lcsh:Gynecology and obstetrics
T-Lymphocytes
Regulatory
03 medical and health sciences
Th2 Cells
0302 clinical medicine
Immune system
Internal medicine
medicine
Humans
Lymph node
lcsh:RG1-991
Neoplasm Staging
030304 developmental biology
Cervical cancer
0303 health sciences
business.industry
lcsh:Public aspects of medicine
HPV infection
Obstetrics and Gynecology
lcsh:RA1-1270
Uterine cervical cancer
General Medicine
Immunologic dissonance
Middle Aged
Th1 Cells
Flow Cytometry
Uterine Cervical Dysplasia
medicine.disease
Tumor Burden
Treg
medicine.anatomical_structure
Reproductive Medicine
Th 17
030220 oncology & carcinogenesis
Cytokines
Th17 Cells
Female
business
Carcinogenesis
Research Article
Zdroj: BMC Women's Health
BMC Women's Health, Vol 20, Iss 1, Pp 1-7 (2020)
ISSN: 1472-6874
DOI: 10.1186/s12905-020-00972-0
Popis: BackgroundNearly all uterine cervical cancer (UCC) cases result from human papillomavirus (HPV) infection. After high-risk HPV infection, most HPV infections are naturally cleared by humoral and cell-mediated immune responses. Thus, cervical lesions of only few patients progress into cervical cancer via cervical intraepithelial neoplasia (CIN) and lead to persistent oncogenic HPV infection. This suggests that immunoregulation plays an instrumental role in the carcinogenesis. However, there was a few studies on the relation between the immunologic dissonance and clinical characteristics of UCC patients.MethodWe examined the related immune cells (Th1, Th2, Th17, and Treg cells) by flow cytometric analysis and analyzed their relations with UCC stages, tumor size, differentiation, histology type, lymph node metastases, and vasoinvasion. Next, we quantified the Th1, Th2, Th17, and Treg cells before and after the operation both in UCC and CIN patients.ResultsWhen compared with stage I patients, decreased levels of circulating Th1 cells and elevated levels of Th2, Th17, and Treg cells were detected in stage II patients. In addition, the imbalance of Th1/Th2 and Th17/Treg cells was related to the tumor size, lymph node metastases, and vasoinvasion. We found that immunological cell levels normalized after the operations. In general, immunological cell levels in CIN patients normalized sooner than in UCC patients.ConclusionsOur findings suggested that peripheral immunological cell levels reflect the patient’s condition.
Databáze: OpenAIRE
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