Evolution of sexually-transferred steroids inAnophelesmosquitoes
| Autor: | Catherine Bourgouin, Nicolas Puchot, Michael Lang, Emilie Pondeville, Francis Schaffner, Floriane Cherrier, Emmanuel Bischoff, Chantal Dauphin-Villemant |
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| Rok vydání: | 2018 |
| Předmět: |
0303 health sciences
media_common.quotation_subject 030231 tropical medicine Malaria vector control Anopheles Zoology Insect Biology medicine.disease biology.organism_classification 3. Good health 03 medical and health sciences 0302 clinical medicine Cellia parasitic diseases medicine Malaria vector Malaria 030304 developmental biology Hormone media_common |
| DOI: | 10.1101/248112 |
| Popis: | Human malaria, which remains a major public health problem, is transmitted by a subset ofAnophelesmosquitoes belonging to only three out of eight subgenera:Anopheles, CelliaandNyssorhynchus. Unlike almost every other insect species, it was shown that males of someAnophelesspecies produce and transfer steroid hormones to females during copulation and that this transfer mediates reproductive changes. Steroids are consequently seen as a potential target for malaria vector control. Here, we analysed the evolution of sexually-transferred steroids and their effects on female reproductive traits acrossAnophelesby using a set of 16 mosquito species (5Anopheles, 8Cellia, and 3Nyssorhynchus), including malaria vector and non-vector species. We show that male steroid production and transfer are specific to theCelliasubgenus and that there is no correlation between mating-induced effects in females and sexually-transferred steroids. In the light of our results, male steroid production, transfer and post-mating effects in females do not correlate with their ability to transmit human malaria, which overturns the suggestion from previous studies and suggests that manipulation of steroid-response pathways in the field should be considered with caution in order to benefit malaria vector control strategies. |
| Databáze: | OpenAIRE |
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