Intra- and Inter-visit Reproducibility of Ganglion Cell–Inner Plexiform Layer Measurements Using Handheld Optical Coherence Tomography in Children With Optic Pathway Gliomas
| Autor: | Chieh-Li Chen, Joel S. Schuman, Graham E. Quinn, Avital Cnaan, Natalie C. Glaug, Robert A. Avery, Hiroshi Ishikawa, Roger J. Packer |
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| Rok vydání: | 2014 |
| Předmět: |
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Optic Nerve Glioma Retinal Ganglion Cells medicine.medical_specialty genetic structures Article Nerve Fibers Optical coherence tomography Ophthalmology medicine Humans Macula Lutea Prospective Studies Child Prospective cohort study Reproducibility medicine.diagnostic_test business.industry Infant Reproducibility of Results Magnetic resonance imaging Anatomy medicine.disease Inner plexiform layer Magnetic Resonance Imaging eye diseases Ganglion Visual field medicine.anatomical_structure ROC Curve Child Preschool Female sense organs Visual Fields Optic nerve glioma business Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | American Journal of Ophthalmology. 158:916-923.e1 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/j.ajo.2014.07.029 |
| Popis: | To determine the intra- and inter-visit reproducibility of ganglion cell-inner plexiform layer thickness measures using handheld optical coherence tomography (OCT) in sedated children with optic pathway gliomas and/or neurofibromatosis type 1 (NF1).Prospective longitudinal cohort study.Children with sporadic optic pathway gliomas and/or NF1 who had ≥2 volumes acquired over the macula using handheld OCT during sedation for clinically indicated magnetic resonance imaging were eligible for the intra-visit cohort. Children with repeat handheld OCT imaging within 6 months were eligible for the inter-visit cohort. Total retinal thickness and ganglion cell-inner plexiform layer thickness were measured using custom-designed automated segmentation software. Reproducibility was compared across average and anatomic quadrant by calculating the coefficient of variation (CV) and intraclass correlation coefficient (ICC).Forty-two subjects (median age 5.4 years, range 0.8-12.7 years) contributed 45 eyes to the intra-visit cohort. Thirty-one subject eyes had normal vision and 14 had abnormal vision (decreased visual acuity and/or visual field). Average and quadrant ganglion cell-inner plexiform layer measures demonstrated CVs ≤4.5% with excellent ICCs (0.935). The superior quadrant CV differed between subjects with (4.4%) and without (2.1%) vision loss (P.05). Twenty-five subject eyes were eligible for the inter-visit cohort, demonstrating CVs from 1.6% to 5.2%. Inter-visit ICCs were excellent (0.955-0.995).Handheld OCT imaging in sedated children with optic pathway gliomas produces highly reproducible measures of ganglion cell-inner plexiform layer thickness. |
| Databáze: | OpenAIRE |
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