Effect of CI-988 on cholecystokinin tetrapeptide-induced panic symptoms in healthy volunteers
| Autor: | Phillip A. Reece, Joanna Hinton, Diana Koszycki, Michel Paradis, Jacques Bradwejn, Allen J. Sedman |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Indoles Molecular Sequence Data Chest pain Placebo CI-988 Tetragastrin Meglumine Double-Blind Method medicine Humans Amino Acid Sequence Biological Psychiatry Psychiatric Status Rating Scales Cross-Over Studies digestive oral and skin physiology Hemodynamics Panic Middle Aged medicine.disease Crossover study Anti-Anxiety Agents Anesthesia Anxiety Chills Receptors Cholecystokinin medicine.symptom Psychology hormones hormone substitutes and hormone antagonists Anxiety disorder |
| Zdroj: | Biological psychiatry. 38(11) |
| ISSN: | 0006-3223 |
| Popis: | A randomized, placebo-controlled, double-blind, three-way crossover design was used to evaluate the effectiveness of single oral 100 mg doses of CI-988, a cholecystokinin B (CCKB) antagonist, in attenuating panic symptoms induced by intravenous injection of cholecystokinin-tetrapeptide (CCK-4). Thirty healthy men received the following treatments on three separate occasions: placebo capsules/placebo, placebo capsules/CCK-4, or CI-988 capsules/CCK-4. There was no marked difference in the number, time to onset, or duration of panic symptoms between CI-988/CCK-4 and placebo/CCK-4. There was, however, a 14% difference in sum intensity scores between these treatments that was statistically significant (p = 0.039). The symptoms most affected by CI-988 were cold chills/hot flushes, chest pain/discomfort, and anxiety/fear/apprehension. Panic attack frequency also decreased following CI-988 treatment (8/30 vs. 16/30; p = 0.035). This decrease, amid otherwise modest effects, could be explained by a preferential effect of CI-988 on the subjective experience of anxiety/fear/apprehension. Possible reasons for the relatively modest effects of CI-988 on CCK-4-induced panic symptoms are discussed. |
| Databáze: | OpenAIRE |
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