Mechanism of Aprindine Induced Agranulocytosis: Direct Toxicity on CFU-C and CFU-GEMM
| Autor: | C Peersman, Hugo Kesteloot, R. L. Verwilghen, Marc Boogaerts, M Peters |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Bone Marrow Cells Pharmacology Biology Megakaryocyte medicine Humans Aged Aprindine Cell growth Macrophages Stem Cells Antibody-Dependent Cell Cytotoxicity Hematology Middle Aged Hematopoiesis Haematopoiesis medicine.anatomical_structure Indenes Toxicity Immunology CFU-GEMM Bone marrow Stem cell Agranulocytosis Granulocytes medicine.drug |
| Zdroj: | Scandinavian Journal of Haematology. 32:175-178 |
| ISSN: | 0036-553X |
| DOI: | 10.1111/j.1600-0609.1984.tb02174.x |
| Popis: | The in vitro bone marrow growth of 2 patients with aprindine-induced agranulocytosis was studied. Granulocyte-macrophage committed stem cell (CFU-C) growth is inhibited by aprindine in a dose dependent manner. 50% inhibition of CFU-colony growth (TD50) was seen at 5.1 and 3.4 micrograms aprindine/ml medium respectively. The TD50 of control marrow CFU-C was 3.2 micrograms/ml. 100% inhibition was seen at 16 micrograms aprindine/ml, both in patients and controls. Pluripotential stem cell growth (CFU-GEMM) in control marrow was equally inhibited in a dose dependent manner by aprindine, though to a lesser extent (TD50: 9.1 micrograms/ml) and with relative sparing of pure megakaryocyte and erythroid colonies. Co-culturing of patients marrows with their respective acute phase serum did not inhibit CFU-C growth. |
| Databáze: | OpenAIRE |
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