NEMP1 Promotes Tamoxifen Resistance in Breast Cancer Cells
| Autor: | Jun Cao, Chuang Tong, Yanyan Liu, Mao-ming Xiong |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antineoplastic Agents Hormonal medicine.medical_treatment Breast Neoplasms Biology Biochemistry Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Genetics medicine Humans Viability assay skin and connective tissue diseases Molecular Biology Ecology Evolution Behavior and Systematics Chemotherapy Cancer Nuclear Proteins General Medicine medicine.disease Nuclear receptor coactivator 1 Tamoxifen 030104 developmental biology ran GTP-Binding Protein Cell culture Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer research MCF-7 Cells Female hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Biochemical genetics. 57(6) |
| ISSN: | 1573-4927 |
| Popis: | Breast cancer (BC) is a worldwide malignant and a leading death cancer in women. Studies have shown that adjuvant tamoxifen reduces the recurrence rate and metastasis in BC. Even though tamoxifen has been used for the therapy of BC for decades, the resistance of it on BC cells could not be ignored. In this study, we first established a tamoxifen-resistant BC cell line and then demonstrated the overexpression of nuclear envelope integral membrane protein 1 (NEMP1) in the tamoxifen-resistant BC cells. Moreover, through a cell viability assay combined with depletion or overexpression technology, we addressed the important role of NEMP1 for the tamoxifen resistance in BC cells. Importantly, we further revealed that NEMP1 modulated tamoxifen resistance by regulating nuclear receptor coactivator 1 (NCOA1). In general, NEMP1 shows responsibility for the resistance of tamoxifen through regulating NCOA1 in BC cells. These results broaden the understanding of the tamoxifen resistance during the chemotherapy in BC and may provide new therapy method for BC. |
| Databáze: | OpenAIRE |
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