Reduced CD26bright expression of peripheral blood CD8+ T-cell subsets in psoriatic patients
Autor: | Piet E.J. van Erp, Rosanne G. Van Lingen, Elke M G J de Jong, Marieke M B Seyger, Jan B.M. Boezeman, Peter C.M. van de Kerkhof |
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Rok vydání: | 2008 |
Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Dipeptidyl Peptidase 4 Population Dermatology CD8-Positive T-Lymphocytes Biochemistry Auto-immunity transplantation and immunotherapy [N4i 4] Blood cell Invasive mycoses and compromised host [N4i 2] Immune Regulation [NCMLS 2] Translational research [ONCOL 3] Psoriasis medicine Cytotoxic T cell Humans education Molecular Biology Chronic inflammation and autoimmunity [UMCN 4.2] education.field_of_study biology business.industry Interleukin-2 Receptor alpha Subunit Antibodies Monoclonal T lymphocyte Middle Aged medicine.disease Flow Cytometry Pathogenesis and modulation of inflammation [N4i 1] medicine.anatomical_structure Immunology biology.protein Biomarker (medicine) Leukocyte Common Antigens Female Antibody business CD8 Immunity infection and tissue repair [NCMLS 1] |
Zdroj: | Experimental Dermatology, 17, 343-8 Experimental Dermatology, 17, 4, pp. 343-8 |
ISSN: | 0906-6705 |
Popis: | Contains fulltext : 71239.pdf (Publisher’s version ) (Closed access) Background: T cells have been shown to be highly relevant in psoriasis. CD26 is a novel T-cell activation marker involved in various T-cell functions, e.g. (i) co-stimulation, (ii) migration and (iii) T-cell memory response. In particular, CD26bright peripheral blood T cells have been shown to be altered in several autoimmune diseases. Objective: To characterize CD26-expression of T-cell subsets in psoriatic patients compared to healthy subjects. Methods: Peripheral blood was obtained from 15 untreated patients with severe psoriasis and from nine healthy subjects. The presence of specific CD26-related T-cell subsets was assessed by flow cytometry. Results: The CD26bright expression of CD8+ lymphocytes revealed a statistically significant (P |
Databáze: | OpenAIRE |
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