Reduced CD26bright expression of peripheral blood CD8+ T-cell subsets in psoriatic patients

Autor: Piet E.J. van Erp, Rosanne G. Van Lingen, Elke M G J de Jong, Marieke M B Seyger, Jan B.M. Boezeman, Peter C.M. van de Kerkhof
Rok vydání: 2008
Předmět:
Adult
CD4-Positive T-Lymphocytes
Male
Dipeptidyl Peptidase 4
Population
Dermatology
CD8-Positive T-Lymphocytes
Biochemistry
Auto-immunity
transplantation and immunotherapy [N4i 4]
Blood cell
Invasive mycoses and compromised host [N4i 2]
Immune Regulation [NCMLS 2]
Translational research [ONCOL 3]
Psoriasis
medicine
Cytotoxic T cell
Humans
education
Molecular Biology
Chronic inflammation and autoimmunity [UMCN 4.2]
education.field_of_study
biology
business.industry
Interleukin-2 Receptor alpha Subunit
Antibodies
Monoclonal
T lymphocyte
Middle Aged
medicine.disease
Flow Cytometry
Pathogenesis and modulation of inflammation [N4i 1]
medicine.anatomical_structure
Immunology
biology.protein
Biomarker (medicine)
Leukocyte Common Antigens
Female
Antibody
business
CD8
Immunity
infection and tissue repair [NCMLS 1]
Zdroj: Experimental Dermatology, 17, 343-8
Experimental Dermatology, 17, 4, pp. 343-8
ISSN: 0906-6705
Popis: Contains fulltext : 71239.pdf (Publisher’s version ) (Closed access) Background: T cells have been shown to be highly relevant in psoriasis. CD26 is a novel T-cell activation marker involved in various T-cell functions, e.g. (i) co-stimulation, (ii) migration and (iii) T-cell memory response. In particular, CD26bright peripheral blood T cells have been shown to be altered in several autoimmune diseases. Objective: To characterize CD26-expression of T-cell subsets in psoriatic patients compared to healthy subjects. Methods: Peripheral blood was obtained from 15 untreated patients with severe psoriasis and from nine healthy subjects. The presence of specific CD26-related T-cell subsets was assessed by flow cytometry. Results: The CD26bright expression of CD8+ lymphocytes revealed a statistically significant (P
Databáze: OpenAIRE
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