Histopathological findings in oesophageal carcinoma with and without preoperative chemotherapy
| Autor: | C W Edwards, S M Allen, H R Matthews, S.J. Darnton |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Esophageal Neoplasms Mitomycin medicine.medical_treatment Adenocarcinoma Gastroenterology Mitomycins Pathology and Forensic Medicine Internal medicine Antineoplastic Combined Chemotherapy Protocols Biopsy Carcinoma Humans Medicine Ifosfamide Aged Neoplasm Staging Aged 80 and over Chemotherapy medicine.diagnostic_test Epithelioma business.industry General Medicine Middle Aged medicine.disease Squamous carcinoma Doxorubicin Carcinoma Squamous Cell Female Histopathology Fluorouracil sense organs Cisplatin business Research Article medicine.drug |
| Zdroj: | Journal of Clinical Pathology. 46:51-55 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.46.1.51 |
| Popis: | AIMS: To investigate the pathological effects of preoperative chemotherapy on oesophageal carcinoma. METHODS: Qualitative and quantitative changes in oesophageal carcinoma after preoperative chemotherapy were assessed by examination of biopsy specimens before treatment and resected specimens. RESULTS: Of 13 patients with adenocarcinoma treated with 5-fluorouracil, adriamycin, and mitomycin (FAM), nine showed minor histological changes compared with 14 control cases. All 12 patients with squamous carcinoma treated with preoperative mitomycin, ifosfamide, and cisplatin (MIC) showed noticeable histological changes when compared with the 13 control cases. Changes included complete ablation (n = 1) and partial regression (n = 5) of the tumour. A quantitative estimate of the proportion of tumour to stroma showed no difference between control adenocarcinomas and those treated with chemotherapy. There was, however, a significant reduction (p < 0.01) in the proportion of tumour to stroma in the treated squamous group compared with the controls. There was no relation between the degree of response in squamous carcinomas and the degree of differentiation of the tumour. Patients in which squamous carcinomas responded well, as assessed quantitatively, showed a tendency to better survival at one year. CONCLUSIONS: Histopathological changes attributable to chemotherapy can be observed in oesophageal carcinoma. The response of squamous carcinoma to MIC is histologically more evident than that of adenocarcinoma to FAM. A quantitative technique may be useful in assessing the effect of chemotherapy in oesophageal squamous carcinoma. |
| Databáze: | OpenAIRE |
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