Influence of anterior chamber morphometrics on endothelial cell changes after phakic intraocular lens implantation
| Autor: | Muriël Doors, Diana W.J.K. Cals, Fred Hendrikse, Tos T. J. M. Berendschot, John de Brabander, Rudy M.M.A. Nuijts, Carroll A.B. Webers |
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| Přispěvatelé: | Oogheelkunde, RS: NUTRIM - R1 - Metabolic Syndrome, RS: CAPHRI School for Public Health and Primary Care |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Phakic Intraocular Lenses Corneal endothelium medicine.medical_specialty Adolescent genetic structures Endothelium Anterior Chamber medicine.medical_treatment Iris Cell Count Intraocular lens Phakic intraocular lens Young Adult Lens Implantation Intraocular Ophthalmology Myopia Humans Medicine Morphometrics Corneal Decompensation business.industry Endothelium Corneal Astigmatism Middle Aged eye diseases Sensory Systems Endothelial stem cell Endothelial cell density Cross-Sectional Studies medicine.anatomical_structure Female Surgery sense organs business Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Journal of Cataract and Refractive Surgery, 34(12), 2110-8. Elsevier Science |
| ISSN: | 0886-3350 |
| DOI: | 10.1016/j.jcrs.2008.08.023 |
| Popis: | Purpose To analyze the position of iris-fixated phakic intraocular lenses (pIOLs) using anterior segment optical coherence tomography (AS-OCT) and evaluate the effect of anterior chamber morphometrics on endothelial cell changes. Setting Department of Ophthalmology, Academic Hospital Maastricht, The Netherlands. Methods In this cross-sectional study, AS-OCT was used to measure the distances from the center and the edges of the pIOL to the corneal endothelium in 242 eyes with various models of myopic pIOLs. Endothelial cell measurements were performed preoperatively and at each follow-up examination. Results The mean follow-up was 34.1 months ± 24.7 (SD) (range 3 months to 7 years). The mean distance between the edge of the pIOL and the endothelium was 1.37 ± 0.22 mm. Although this distance was smaller than the safety value of 1.50 mm in 68.6% of the eyes, no eye developed corneal decompensation. There was a significant endothelial cell density (ECD) loss of 1.28% ± 8.46%, 3.25% ± 8.24%, and 5.02% ± 10.40% at 2 years, 5 years, and 7 years, respectively. Linear mixed-model analysis predicted a yearly ECD loss of 0.98% for a mean edge distance of 1.37 mm, 0.15% for an edge distance of 1.59 mm (mean plus 1 SD), and 1.80% for an edge distance of 1.15 mm (mean minus 1 SD). Conclusions A shorter distance between the edge of the pIOL and the endothelium was significantly associated with higher ECD loss. For safety reasons, the postoperative examination should include long-term evaluation of the anterior chamber morphometrics in addition to ECD counts. |
| Databáze: | OpenAIRE |
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