A single dose of ceftriaxone administered 30 minutes before percutaneous endoscopic gastrostomy significantly reduces local and systemic infective complications
| Autor: | Heiko Risius, Thomas Grünewald, Arno J. Dormann, Hans Huchzermeyer, Friedhelm Kleimann, Axel Kloppenborg, Bernd Wigginghaus |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Antibiotics Bacteremia Drug Costs Enteral Nutrition Percutaneous endoscopic gastrostomy Neoplasms Sepsis Gastroscopy medicine Humans Surgical Wound Infection Economics Pharmaceutical Prospective Studies Aged Gastrostomy Suppuration Hepatology business.industry Stomach Ceftriaxone Gastroenterology Exudates and Transudates Pneumonia Antibiotic Prophylaxis Surgery Cephalosporins medicine.anatomical_structure Multicenter study Erythema Anesthesia Chemoprophylaxis Female Nervous System Diseases business Complication medicine.drug Follow-Up Studies |
| Zdroj: | The American journal of gastroenterology. 94(11) |
| ISSN: | 0002-9270 |
| Popis: | The aim of this study was to determine the efficacy of antibiotic prophylaxis in percutaneous endoscopic gastrostomy (PEG).An open prospective, randomised, multicenter study was conducted in 141 patients; 72 received ceftriaxone 1 g i.v. 30 min preintervention, and 69 received no study medication. A standardized protocol was followed for PEG preparation, insertion, and aftercare; all patients received a 15-Fr gastrostomy tube. Follow-up of local and systemic infection and clinical course was continued to postintervention day 10. An aggregate erythema and exudation score3 or the presence of pus was taken as indicative of peristomal infection. The pharmacoeconomics of antibiotic use were also examined.In no-prophylaxis patients, wound infection rates were 25% on day 4 and 26.4% on day 10, versus 10.1% (p = 0.03) and 14.5% (p = 0.10), respectively, in prophylaxis patients. Results were disproportionally better in tumor patients: systemic infection rates were 16.7% versus 5.8% in no-prophylaxis versus prophylaxis patients (p = 0.045), and overall infection rates 38.9% versus 17.4%, respectively (p = 0.046). Pneumonia was more frequent in patients with underlying neurological disease. Antibiotic costs were the same in both groups (p = 0.792).Single dose ceftriaxone 1 g is an effective prophylaxis against local and systemic infection after PEG. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|