Different effects of the immunostimulatory drug Stimforte on infections of hepatitis C virus and herpes simplex virus type 1
| Autor: | D. V. Mishin, A. V. Ilyichev, G. A. Galegov, A. A. Balakina, E. I. Isaeva, D. G. Mal’dov, S. S. Grigorian, V. L. Andronova, P. G. Deryabin, A. A. Terentyev |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Drug Male viruses media_common.quotation_subject Hepatitis C virus Hepacivirus Herpesvirus 1 Human Biology medicine.disease_cause Virus Replication Antiviral Agents General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Mice 0302 clinical medicine Immune system Herpes virus Interferon Chlorocebus aethiops medicine Cytotoxic T cell Animals Immunologic Factors Vero Cells media_common Mice Inbred BALB C General Immunology and Microbiology Herpes Simplex General Medicine Virology Hepatitis C Killer Cells Natural 030104 developmental biology Herpes simplex virus Vero cell 030211 gastroenterology & hepatology Interferons General Agricultural and Biological Sciences medicine.drug |
| Zdroj: | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 477(1) |
| ISSN: | 1608-3105 |
| Popis: | Stimforte, an immune response-stimulating preparation, is active with respect to hepatitis C virus (HCV) and herpes simplex virus type I (HSV-1). The effects of Stimforte in animals infected with either HCV or HSV-1 are fundamentally different. In mice with acute herpes virus infection, Stimforte administration leads to a higher activity of natural killer cells and cytotoxic lymphocytes, and the amount of interferon (IFN) λ grows. In mice infected with HCV, Stimforte administration results in a significant increase in IFN-β but not IFN-λ in blood and affected organs. Stimforte has been found to affect directly HCV reproduction that causes the infected cell death, but it does not affect HSV-1 reproduction in the Vero cells (V). |
| Databáze: | OpenAIRE |
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