Hepatitis E virus infections in Europe
| Autor: | Jacques Izopet, Nicolas Capelli, Florence Abravanel, Sébastien Lhomme, Olivier Marion, Jean-Michel Mansuy, Sabine Chapuy-Regaud, Marion Migueres, Pauline Trémeaux, Nassim Kamar |
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| Přispěvatelé: | Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Virologie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service de Virologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département de Néphrologie et Transplantation d'organes [CHU Toulouse], Pôle Urologie - Néphrologie - Dialyse - Transplantations - Brûlés - Chirurgie plastique - Explorations fonctionnelles et physiologiques [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CCSD, Accord Elsevier |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
viruses [SDV]Life Sciences [q-bio] Iatrogenic Disease medicine.disease_cause MESH: Genotype Zoonosis 0302 clinical medicine Hepatitis E virus Zoonoses Epidemiology MESH: Animals 030212 general & internal medicine [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology Incidence (epidemiology) MESH: Hepatitis E virus / genetics virus diseases Hepatitis E 3. Good health Hospitalization Europe [SDV] Life Sciences [q-bio] Infectious Diseases One Health [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology RNA Viral MESH: Hospitalization / statistics & numerical data MESH: Hepatitis E virus / pathogenicity Viral hepatitis Water Microbiology medicine.medical_specialty Genotype 030106 microbiology MESH: Iatrogenic Disease / epidemiology MESH: Zoonoses / virology MESH: Hepatitis E / diagnosis 03 medical and health sciences Virology medicine Seroprevalence Animals Humans MESH: Food Microbiology MESH: Hepatitis E / epidemiology MESH: Humans business.industry medicine.disease MESH: Europe / epidemiology digestive system diseases MESH: Water Microbiology MESH: Zoonoses / epidemiology [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Food Microbiology [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie MESH: RNA Viral / genetics business |
| Zdroj: | Journal of Clinical Virology Journal of Clinical Virology, Elsevier, 2019, 120, pp.20-26. ⟨10.1016/j.jcv.2019.09.004⟩ Journal of Clinical Virology, 2019, 120, pp.20-26. ⟨10.1016/j.jcv.2019.09.004⟩ |
| ISSN: | 1386-6532 1873-5967 |
| DOI: | 10.1016/j.jcv.2019.09.004⟩ |
| Popis: | International audience; Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. The systematic use of improved tools for diagnosing and genotyping has completely changed our understanding of the epidemiology and clinical consequences of HEV infection. Most cases of HEV in Europe arise from infected animals such as pigs, wild boar, deer and rabbits. Zoonotic HEV genotypes (HEV genotypes 3-8) are mainly food-borne or transmitted by direct contact, but recent data suggest that infection can also be water-borne or even iatrogenic throught contamined blood products. HEV-3 is the most prevalent genotype in Europe but the geographic distributions of the 3 major clades and subgenotypes (HEV-3abjkchi, HEV-3efg, and HEV-3ra) differ. Most HEV-3 infections are asymptomatic but they can result in severe acute hepatitis in patients with chronic liver disease, chronic hepatitis in immunocompromised patients, and to extra-hepatic manifestations. Despite more frequent reports of symptomatic hepatitis E cases across Europe, systems for monitoring HEV infections vary greatly. Severe HEV-associated illnesses, hospitalizations and deaths are probably underestimated. The seroprevalence and incidence of locally acquired hepatitis E varies between and within European countries and over time. The precise origin of these variations is uncertain but may be linked to environmental factors or the degree to which HEV contaminates the human food chain. Collaborative initiatives such as the establishment of the One Health platform for HEV sequences (HEVnet database) will be very useful for a better understanding of the epidemiology of HEV in Europe and the development of effective prevention strategies. |
| Databáze: | OpenAIRE |
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