Primary squamous cell carcinoma of the breast: report of two cases with HER2 overexpression
| Autor: | Ruixue Lei, Lanfang Miao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Cancer Research Receptor ErbB-2 Breast Neoplasms Review 03 medical and health sciences 0302 clinical medicine Immunophenotyping Humans Medicine Basal cell skin and connective tissue diseases neoplasms Retrospective Studies Pharmacology business.industry Middle Aged 030104 developmental biology Oncology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research Molecular Medicine Female business |
| Zdroj: | Cancer Biol Ther |
| ISSN: | 1555-8576 1538-4047 |
| DOI: | 10.1080/15384047.2020.1838033 |
| Popis: | Objective To investigate the clinicopathologic features and immunophenotype of primary squamous cell carcinoma of the breast (PSCCB) with HER2 overexpression. Methods Two cases of PSCCB with HER2 overexpression were retrospectively reviewed, and the pathological features, immunophenotype and prognosis were discussed. Results The tumor showed malignant squamous cells arranged in sheets, groups and nests, forming keratin-pearl and intercellular bridges. Immunohistochemical (IHC) analysis showed that the tumor cells were positive for 34βE12, p63, CK5/6, E-cadherin and P120, while negative for ER and PR. Furthermore, HER2 overexpression showed strong continuous expression in cell membrane with a score of 3+ by IHC, or amplification by FISH. Conclusions PSCCB is a rare tumor in breast cancer and HER2 overexpression is rather unusual in PSCCB. The diagnosis mainly depends on the clinicopathologic features together with the immunophenotype. HER2 positive indicates poor prognosis. However, targeted therapy for HER2 may be a new hope for patients. |
| Databáze: | OpenAIRE |
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