Effect of varenicline on behavioral deficits in a rat model of Parkinson's disease induced by unilateral 6-hydroxydopamine lesion of substantia nigra

Autor: Atsushi Yamauchi, Öznur Açikalin, Izzettin Hatip-Al-Khatib, Funda F. Bölükbaşı Hatip, Yasufumi Kataoka, Ruyal F Tan
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Parkinson's disease
Apomorphine
Dopamine
experimental parkinsonism
6-hydroxydopamine
Pharmacology
Receptors
Nicotinic
animal behavior
Rats
Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
rat
animal
Nicotinic Agonists
Varenicline
comparative study
injuries
reinforcement
Sprague Dawley rat
Behavior
Animal
drug effect
Parkinson Disease
behavior disorder
locomotion
Substantia Nigra
Psychiatry and Mental health
varenicline
Nicotinic agonist
behavioral deficits
nicotinic agent
rotarod test
motor dysfunction
medicine.drug
Agonist
vibrissae elicited forelimb placing
animal structures
medicine.drug_class
animal experiment
Substantia nigra
Motor Activity
Partial agonist
psychopharmacotherapy
Article
Varenicline Tartrate
forelimb
03 medical and health sciences
oxidopamine
medicine
Animals
controlled study
Oxidopamine
corpus striatum
forelimb asymmetry
nonhuman
treatment duration
business.industry
animal model
disease model
rearing
medicine.disease
Corpus Striatum
Rats
Disease Models
Animal
030104 developmental biology
chemistry
nervous system
apomorphine test
brain asymmetry
physiology
business
nicotinic receptor
metabolism
030217 neurology & neurosurgery
Popis: Nicotinic acetylcholine receptors (nAChRs) are implicated in the pathogenesis of Parkinson's disease (PD). Varenicline tartrate is a partial agonist at ?4ß2 and full agonist at ?7 neuronal nAChR subunits. A unilateral lesion of the substantia nigra (SN) has been used as a reliable model of PD. This study aimed to investigate the effect of varenicline on locomotor and nonlocomotor behavioral deficits induced by a unilateral lesion of the SN induced by 6-hydroxydopamine (6-OHDA) (8 g/4 l). Varenicline (1 mg/kg) was administered to the lesioned rats daily for 2 weeks, which commenced 3 weeks after 6-OHDA administration. The results showed that varenicline improved motor deficits induced by 6-OHDA. It improved locomotor and nonlocomotor activities such as forelimb use, rotarod performance, and forelimb asymmetry. Varenicline did not change rearing or vibrissae-elicited forelimb placing but did increase apomorphine-induced rotation. In conclusion, the present results suggest that drugs with specific partial/full agonistic activity on nAChR subunits could be of value in the treatment of neurodegenerative disorders such as PD. © 2018 Wolters Kluwer Health, Inc. All rights reserved.
Databáze: OpenAIRE
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