Roseopurpurins: Chemical Diversity Enhanced by Convergent Biosynthesis and Forward and Reverse Michael Additions
| Autor: | Zeinab G. Khalil, Pabasara Kalansuriya, Michelle Quezada, Li Li, Zhuo Shang, Angela A. Salim, Robert J. Capon |
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| Rok vydání: | 2016 |
| Předmět: |
Penicillium roseopurpureum
Dose-Response Relationship Drug Molecular Structure Cell Survival 010405 organic chemistry Stereochemistry Organic Chemistry Penicillium 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Structure-Activity Relationship chemistry.chemical_compound Biosynthesis chemistry Cell Line Tumor Polyketides Biological property Chemical diversity Michael reaction Humans Organic chemistry Prodrugs Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 18:4340-4343 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | Cultures of the estuarine fungus Penicillium roseopurpureum (CMB-MF038) yielded a diverse array of polyketides, many of which were related via a highly convergent biosynthetic pathway. In addition to revising and assigning structures, and documenting chemical and biological properties, pro-drug cytotoxic properties were attributed to roseopurpurins H (10) and I (11) on the basis of in situ reverse Michael addition to a cytotoxic Michael acceptor (12). |
| Databáze: | OpenAIRE |
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