Low cefpirome levels during twice daily dosing in critically ill septic patients: pharmacokinetic modelling calls for more frequent dosing
| Autor: | David Fraenkel, Jeffrey Lipman, Steven C. Wallis, Claire M. Rickard |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Critical Illness Renal function Critical Care and Intensive Care Medicine Bolus (medicine) Pharmacokinetics Sepsis Medicine Humans Dosing Prospective Studies Infusions Intravenous Antibacterial agent APACHE Aged business.industry Cefpirome Middle Aged Cephalosporins Intensive Care Units Treatment Outcome Anesthesia Pharmacodynamics Area Under Curve Trough level Female business medicine.drug Half-Life |
| Zdroj: | Intensive care medicine. 27(2) |
| ISSN: | 0342-4642 |
| Popis: | Objectives: To measure plasma levels and pharmacokinetics of cefpirome in critically ill septic patients with normal renal function. To use the pharmacokinetic model to simulate alternate dosing regimens and identify those that predict sustained levels. Design and setting: A prospective, open-label, descriptive study in a 22-bed, multidisciplinary, adult ICU in a university-affiliated, tertiary referral hospital. Patients: Twelve adults with normal renal function on enrolment and with suspected or documented sepsis in whom cefpirome was judged to be the appropriate therapy by the managing clinician. Interventions: Cefpirome 2 g was infused intravenously over 3 min every 12 h. Timed blood samples were taken prior to and during two dosing intervals. Urine was collected for creatinine clearance determination. Measurements and results: Two patients were non-evaluable due to renal dysfunction post-enrolment. The median cefpirome trough level was 1.1 mg/l (range 0.5–8.1 mg/l) after the initial dose and 1.4 mg/l (range |
| Databáze: | OpenAIRE |
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