Analgesic Effects of Danggui-Shaoyao-San on Various 'Phenotypes' of Nociception and Inflammation in a Formalin Pain Model
| Autor: | Jun-Ping Kou, Wen Wang, Ting Zhang, Huang-Hui Wu, Ke-Cheng Zhou, Jun-Bin Yin, Tan Ding, Alan D. Kaye, Li-Ying Wang, Wei Hu |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Nociception 0301 basic medicine Serotonin Injections Subcutaneous Analgesic Neuroscience (miscellaneous) Pain Pharmacology 03 medical and health sciences Cellular and Molecular Neuroscience Subcutaneous injection 0302 clinical medicine Formaldehyde Edema Animals Medicine Inflammation Neurons Analgesics Hypoalgesia Behavior Animal business.industry Dextran Sulfate Spinal cord Mice Inbred C57BL Disease Models Animal Phenotype 030104 developmental biology medicine.anatomical_structure Spinal Cord Neurology Cyclooxygenase 2 Anesthesia Hyperalgesia medicine.symptom business Licking 030217 neurology & neurosurgery Drugs Chinese Herbal |
| Zdroj: | Molecular Neurobiology. 53:6835-6848 |
| ISSN: | 1559-1182 0893-7648 |
| DOI: | 10.1007/s12035-015-9606-3 |
| Popis: | Danggui-Shaoyao-San (DSS) is a traditional Chinese medicine, which has long been used for pain treatment and has been demonstrated to possess anti-oxidative, cognitive enhancement, and anti-depressant effects. In the present study, the effects of aqueous extracts of DSS on spontaneous pain behaviors and long-term hyperalgesia were examined to investigate the anti-nociceptive effects and underlying mechanisms. Single pretreatment of DSS dose-dependently reduced spontaneous flinches/licking time in the second, rather than the first, phase after subcutaneous injection of 5 % formalin into one hindpaw, in doses of 2.4 and 9.6 g/kg. DSS also dose-dependently inhibited FOS and cyclooxygenase-2 (COX-2) expression in both superficial and deep layers within the spinal dorsal horn. Further, DSS reduced hypoalgesia in the injected paw from 1 to 3 days and produced anti-hyperalgesic actions in both the injected paw after 3 days and non-injected paw. These data suggest involvement of enhancement of descending pain inhibition by suppression of 5-HTT levels in the spinal dorsal horn and reduction of peripheral long-term inflammation, including paw edema and ulcers. These findings suggest that DSS may be a useful therapeutic agent for short- and long-term inflammation induced pain, through both anti-inflammatory and suppression of central sensitization mechanisms. |
| Databáze: | OpenAIRE |
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