Non-Nutritive Sweeteners and Their Implications on the Development of Metabolic Syndrome
| Autor: | Fady Dawoud, Yatin Riat, Bessi Qorri, Myron R. Szewczuk, Iryna Liauchonak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
non-nutritive sweeteners type 2 diabetes mellitus 030209 endocrinology & metabolism lcsh:TX341-641 Review Gut flora Bioinformatics Receptors G-Protein-Coupled 03 medical and health sciences 0302 clinical medicine GPCR medicine Humans Obesity Nutritive Sweeteners Metabolic Syndrome 2. Zero hunger Nutrition and Dietetics biology gut microbiota Type 2 Diabetes Mellitus medicine.disease biology.organism_classification Receptor Insulin Gastrointestinal Microbiome insulin receptor signaling MicroRNAs Insulin receptor Crosstalk (biology) 030104 developmental biology Diabetes Mellitus Type 2 miRNAs biology.protein Dysbiosis sense organs Metabolic syndrome lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients, Vol 11, Iss 3, p 644 (2019) Nutrients |
| ISSN: | 2072-6643 |
| Popis: | Individuals widely use non-nutritive sweeteners (NNS) in attempts to lower their overall daily caloric intake, lose weight, and sustain a healthy diet. There are insufficient scientific data that support the safety of consuming NNS. However, recent studies have suggested that NNS consumption can induce gut microbiota dysbiosis and promote glucose intolerance in healthy individuals that may result in the development of type 2 diabetes mellitus (T2DM). This sequence of events may result in changes in the gut microbiota composition through microRNA (miRNA)-mediated changes. The mechanism(s) by which miRNAs alter gene expression of different bacterial species provides a link between the consumption of NNS and the development of metabolic changes. Another potential mechanism that connects NNS to metabolic changes is the molecular crosstalk between the insulin receptor (IR) and G protein-coupled receptors (GPCRs). Here, we aim to highlight the role of NNS in obesity and discuss IR-GPCR crosstalk and miRNA-mediated changes, in the manipulation of the gut microbiota composition and T2DM pathogenesis. |
| Databáze: | OpenAIRE |
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