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The current study aims to determine the expression of Trefoil factor 2 (TFF2), Trefoil factor 3 (TFF3) and Adrenomedullin (ADM) in salivary samples of periodontitis patients with and without coronary heart disease (CHD).A total of 75 patients were selected based on the inclusion and exclusion criteria and divided into 3 groups: Generalised periodontitis (GP) group: 25 generalised periodontitis patients only, GP+CHD group: 25 patients both with generalised periodontitis and coronary heart disease. CHD group: 25 coronary heart disease patients only. Demographic, periodontal and cardiac parameters were recorded, unstimulated saliva samples were collected and analysed for the expression of TFF2, TFF3 and ADM.Among the demographic variables, the mean difference of age, weight and body mass index (BMI) were significantly different between the groups on statistical analysis. Plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL) and the expression of TFF2 were highest in GP+CHD and ADM was seen to be higher in CHD with p value0.01 as compared to the other groups. TFF2, TFF3 and ADM were also correlated with the demographic and periodontal parameters.The study demonstrates significantly elevated levels of TFF2 in coronary heart disease and generalised periodontitis and the higher expression of ADM in coronary heart disease only, suggesting the possibility of an underlying inflammatory mechanism. This article is protected by copyright. All rights reserved. |
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