Donovanosis and squamous cell carcinoma: The relationship conundrum!
| Autor: | Tarun Narang, Uma Nahar Saikia, Muthu Sendhil Kumaran, Amanjot Kaur Arora, Sanjeev Handa |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Klebsiella granulomatis Granuloma Inguinale medicine.medical_specialty Biopsy Dermatology Malignancy Malignant transformation 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Scrotum Humans Medicine Pharmacology (medical) Ulcer Groin medicine.diagnostic_test business.industry Public Health Environmental and Occupational Health 030206 dentistry medicine.disease Anti-Bacterial Agents Granuloma inguinale Basophilic Infectious Diseases medicine.anatomical_structure Doxycycline Carcinoma Squamous Cell business Penis |
| Zdroj: | International Journal of STD & AIDS. 28:411-414 |
| ISSN: | 1758-1052 0956-4624 |
| DOI: | 10.1177/0956462416665996 |
| Popis: | Donovanosis is a rare, chronic and indolent sexually transmitted infection caused by Klebsiella granulomatis. The ulcers in donovanosis rarely undergo malignant transformation, which is usually seen in longstanding ulcers. We present a case of a 32-year-old male who presented with a two-month history of rapidly progressive, large, foul-smelling ulcers over the groin, distal penile shaft and scrotum. Crushed tissue smears from ulcers revealed basophilic intracellular and extracellular Donovan bodies. Fine needle aspiration cytology from inguinal lymph nodes and biopsy from the ulcers revealed well-differentiated squamous cell carcinoma. The current case aims to alert clinicians that donovanosis is a rare but possible cause of cutaneous malignancy. Nonetheless, the pathogenesis of malignant transformation in donovanosis needs further research. |
| Databáze: | OpenAIRE |
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