Resistance of aspirin during and after pregnancy: A longitudinal cohort study
| Autor: | Carolien N.H. Abheiden, Wessel W. Fuijkschot, Marjon A. de Boer, Ankie M. Harmsze, Johanna I. P. de Vries, Jeske M. bij de Weg, Abel Thijs |
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| Přispěvatelé: | Obstetrics and gynaecology, Internal medicine, Amsterdam Reproduction & Development (AR&D), ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, AGEM - Inborn errors of metabolism, Amsterdam Movement Sciences - Restoration and Development, ACS - Atherosclerosis & ischemic syndromes |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Light transmission medicine.medical_specialty Platelet Function Tests Drug Resistance Drug resistance 030204 cardiovascular system & hematology Third trimester Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Internal medicine Placenta Internal Medicine medicine Humans Longitudinal Studies Longitudinal cohort Aspirin 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Hypertension Pregnancy-Induced medicine.disease Thromboxane B2 medicine.anatomical_structure chemistry Female Pregnancy Trimesters business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | bij de Weg, J M, Abheiden, C N H, Fuijkschot, W W, Harmsze, A M, de Boer, M A, Thijs, A & de Vries, J I P 2020, ' Resistance of aspirin during and after pregnancy: A longitudinal cohort study ', Pregnancy Hypertension, vol. 19, pp. 25-30 . https://doi.org/10.1016/j.preghy.2019.11.008 Pregnancy Hypertension, 19, 25-30. Elsevier BV |
| ISSN: | 2210-7789 |
| DOI: | 10.1016/j.preghy.2019.11.008 |
| Popis: | Objectives The objective of this study is to investigate possible changes in aspirin resistance during and after pregnancy over time. Study design A longitudinal cohort study in obstetric high risk women with an indication for aspirin usage during pregnancy to prevent placenta mediated pregnancy complications. Main outcome measures Aspirin resistance measured in the first, second and third trimester of pregnancy and at least three months postpartum by four complementary test: PFA-200, VerifyNow®, Chronolog light transmission aggregometry (Chronolog LTA) and serum thromboxane B2 (TxB2) level measurements. Correlation between the devices was investigated. Results In total, 23 pregnant women participated in the present study. Aspirin resistance according to the PFA-200, VerifyNow®, Chronolog LTA and serum TxB2, was 30.4%, 17.4%, 26.1% and 23.8% respectively. Resistance by any device was 69.6%. Aspirin resistance measured by the VerifyNow®, Chronolog LTA, serum TxB2 and aspirin resistance by any device during pregnancy was demonstrated more frequently than aspirin resistance after pregnancy. Correlation between the different devices was weak. Conclusion Aspirin resistance was found in a considerable part of the participants. Considerable variation between participants, within participants over time and between the different devices was found. Prevalence of aspirin resistance during pregnancy differs from after pregnancy. More research on aspirin resistance and clinical obstetric outcome is needed. |
| Databáze: | OpenAIRE |
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