Characterization of atrial histopathological and electrophysiological changes in a mouse model of aging
| Autor: | Tao Luo, Cui-Xian Chang, Shi-Kui Gu, Yu-Ming Li, Tie-Ming Jiang, Xin Zhou |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Aging medicine.medical_specialty Left atrium Electrocardiography Mice Heart Rate Fibrosis Internal medicine Atrial Fibrillation Genetics medicine Animals Repolarization Myocytes Cardiac Heart Atria Patch clamp Atrial myocytes business.industry Atrial fibrillation General Medicine medicine.disease Electrophysiological Phenomena Electrophysiology Endocrinology medicine.anatomical_structure Models Animal Potassium cardiovascular system Cardiology Right atrium business |
| Zdroj: | International Journal of Molecular Medicine. 31:138-146 |
| ISSN: | 1791-244X 1107-3756 |
| DOI: | 10.3892/ijmm.2012.1174 |
| Popis: | The detailed mechanisms of age-related atrial structural and electrophysiological changes remain elusive. Small animal models have recently been used for the investigation of atrial tachyarrhythmia. In this study, we investigated the hypothesis that atrial structural and electrical characterization with aging provides a substrate for atrial fibrillation using a mouse model of aging. Male Kunming mice aged 2 (young), 12 (middle-aged) and 24 months (aged) were used in this study. A surface electrocardiogram and sinus node recovery time (SNRT) were recorded at baseline. Atrial fibrillation (AF) inducibility and duration were measured by a transesophageal electrode catheter. Collagen content was assessed by the collagen volume fraction. Whole cell configuration using the patch clamp technique was performed for the transient outward potassium (Ito) and ultra-rapid delayed rectifier potassium (Ikur) currents. P-wave duration, SNRT and rate-corrected SNRT were longer in the aged group than in the remaining 2 groups, paralleled by inducibility significantly being increased in the aged group. The right atrium had significantly higher levels of fibrosis than the left atrium in all the groups (P |
| Databáze: | OpenAIRE |
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