Bioaccessibility and bioavailability of environmental semi-volatile organic compounds via inhalation. A review of methods and models

Autor: Philippe Glorennec, Gaëlle Raffy, Nathalie Bonvallot, Åsa Gustafsson, Corinne Mandin, Barbara Le Bot, Annette M. Krais, Olivier Ramalho, Wenjuan Wei
Přispěvatelé: Centre Scientifique et Technique du Bâtiment (CSTB), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), EHESP-Irset (EHESP-Irset), École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Santé Environnement Travail et Génie Sanitaire (DSETGS), Umeå University, Laboratoire d'étude et de recherche en environnement et santé (LERES), Lund University [Lund], FP7/2007-2013, FP7, Seventh Framework Programme, PRESTIGE-2015-3-0016, Campus France, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Karolinska Institute, Département Méthodes quantitatives en santé publique (METIS), This research received funding from the People Program (Marie Curie Actions) of the European Union Seventh Framework Programme (FP7/2007-2013) under REA grant agreement n. PCOFUND-GA-2013-609102, through the PRESTIGE Program coordinated by Campus France (PRESTIGE-2015-3-0016).
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Polychlorinated Dibenzodioxins
Future studies
Respiratory System
Biological Availability
Respiratory tract
010501 environmental sciences
Models
Biological
01 natural sciences
In vivo tests
Absorption
03 medical and health sciences
Adverse health effect
Animals
Humans
Respiratory cycle
Polycyclic Aromatic Hydrocarbons
Deposition
lcsh:Environmental sciences
0105 earth and related environmental sciences
General Environmental Science
lcsh:GE1-350
Inhalation exposure
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology
environment/Health
Air Pollutants
Volatile Organic Compounds
Inhalation
Semi-volatile organic compounds SVOCs
Internal dose
3. Good health
Bioavailability
030104 developmental biology
13. Climate action
Air Pollution
Indoor
Environmental chemistry
Environmental science
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Biological variability
Zdroj: Environment International
Environment International, Elsevier, 2018, 113, pp.202-213. ⟨10.1016/j.envint.2018.01.024⟩
Environment International, Vol 113, Iss, Pp 202-213 (2018)
Environment International, 2018, 113, pp.202-213. ⟨10.1016/j.envint.2018.01.024⟩
ISSN: 0160-4120
Popis: Semi-volatile organic compounds (SVOCs) present in indoor environments are known to cause adverse health effects through multiple routes of exposure. To assess the aggregate exposure, the bioaccessibility and bioavailability of SVOCs need to be determined.In this review, we discussed measurements of the bioaccessibility and bioavailability of SVOCs after inhalation. Published literature related to this issue is available for 2,3,7,8-tetrachlorodibenzo-p-dioxin and a few polycyclic aromatic hydrocarbons, such as benzo[a]pyrene and phenanthrene. Then, we reviewed common modeling approaches for the characterization of the gas- and particle-phase partitioning of SVOCs during inhalation. The models are based on mass transfer mechanisms as well as the structure of the respiratory system, using common computational techniques, such as computational fluid dynamics. However, the existing models are restricted to special conditions and cannot predict SVOC bioaccessibility and bioavailability in the whole respiratory system.The present review notes two main challenges for the estimation of SVOC bioaccessibility and bioavailability via inhalation in humans. First, in vitro and in vivo methods need to be developed and validated for a wide range of SVOCs. The in vitro methods should be validated with in vivo tests to evaluate human exposures to SVOCs in airborne particles. Second, modeling approaches for SVOCs need to consider the whole respiratory system. Alterations of the respiratory cycle period and human biological variability may be considered in future studies. Keywords: SVOCs, Respiratory tract, Absorption, Deposition, Inhalation exposure, Internal dose
Databáze: OpenAIRE
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