Lack of α2-adrenergic antilipolytic effect during exercise in subcutaneous adipose tissue of trained men
| Autor: | Michel Berlan, Daniel Rivière, J. Hejnova, J. M. Cottet-Emard, I. De Glisezinski, François Crampes, F. Marion-Latard, Vladimir Stich |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Blood Glucose Glycerol Male medicine.medical_specialty Microdialysis Physiology Lipolysis Adipose tissue Physical exercise Fatty Acids Nonesterified Body Mass Index Catecholamines Oxygen Consumption Phentolamine Receptors Adrenergic alpha-2 Physiology (medical) Internal medicine medicine Humans Insulin α2 adrenergic Receptor Exercise Adrenergic alpha-Antagonists business.industry Lipid Metabolism Endocrinology Adipose Tissue Physical Fitness Body Composition Catecholamine business medicine.drug |
| Zdroj: | Journal of Applied Physiology. 91:1760-1765 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | The aim of this study was to investigate the involvement of the antilipolytic α2-adrenergic receptor pathway in the regulation of lipolysis during exercise in subcutaneous abdominal adipose tissue (SCAAT). Seven trained men and 15 untrained men were studied. With the use of microdialysis, the extracellular glycerol concentration was measured in SCAAT at rest and during 60 min of exercise at 50% of maximal oxygen consumption. One microdialysis probe was perfused with Ringer solution; the other was supplemented with phentolamine (α2-adrenergic receptor antagonist). No differences in baseline extracellular or plasma glycerol concentrations were found between the two groups. The exercise-induced extracellular and plasma glycerol increase was higher in trained compared with untrained subjects ( P < 0.05). Addition of phentolamine to the perfusate enhanced the exercise-induced response of extracellular glycerol in untrained subjects but not in trained subjects. The exercise-induced increase in plasma norepinephrine and epinephrine concentrations and the decrease in plasma insulin were not different in the two groups. These in vivo findings demonstrate higher exercise-induced lipolysis in trained compared with untrained subjects and show that, in trained subjects, the α2-mediated antilipolytic action is not involved in the regulation of lipolysis in SCAAT during exercise. |
| Databáze: | OpenAIRE |
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