Acute lesions of the ventromedial hypothalamus reduce sympathetic activation and thermogenic changes induced by PGE1
| Autor: | Andrea Viggiano, A. Sullo, M. P. Pellicano, Marcellino Monda, V. De Luca |
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| Přispěvatelé: | Monda, Marcellino, Sullo, A, DE LUCA, V, Viggiano, A, Pellicano, Mp |
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Male
Hyperthermia Sympathetic nervous system medicine.medical_specialty Sympathetic Nervous System Colon Intraventricular medicine.medical_treatment Adipose tissue Adipose Tissue Brown innervation/physiology Alprostadil physiology Animals Body Temperature Regulation physiology Colon physiology Electrophysiology Injections Intraventricular Male Rats Rats Sprague-Dawley Sympathetic Nervous System physiology Ventromedial Hypothalamic Nucleus physiology innervation/physiology Injections Rats Sprague-Dawley Lesion chemistry.chemical_compound Adipose Tissue Brown Physiology (medical) Internal medicine Brown adipose tissue medicine Animals Alprostadil Prostaglandin E1 Saline Injections Intraventricular business.industry General Neuroscience medicine.disease Rats Electrophysiology medicine.anatomical_structure Endocrinology chemistry Ventromedial Hypothalamic Nucleus Hypothalamus Sprague-Dawley medicine.symptom business Body Temperature Regulation |
| Popis: | The aim of this experiment was to evaluate the effects of an intracerebroventricular (icv) injection of prostaglandin E1 (PGE 1 ) on the sympathetic activation and the thermogenic changes in rats with acute lesions of the ventromedial hypothalamus (VMH). Four groups of six Sprague-Dawley male rats were anesthetized with ethyl-urethane. The firing rate of the sympathetic nerves innervating the interscapular brown adipose tissue (IBAT) and the colonic and IBAT temperatures were monitored both before and after one of the following treatments: 1) VMH lesion plus icv injection of PGE 1 (500 ng); 2) VMH lesion plus icv injection of saline; 3) sham lesion plus icv injection of PGE 1 ; and 4) sham lesion plus icv injection of saline. PGE 1 induced an increase in the firing rate of IBAT nerves and the colonic and IBAT temperatures. These effects were reduced by VMH lesion. The findings indicate that acute lesions of the VMH reduce the effects of PGE 1 and seem to suggest a possible role played by the VMH in the control of the sympathetic activation and the thermogenic changes during PGE 1 hyperthermia. |
| Databáze: | OpenAIRE |
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