Vaccinomics and Adversomics in the Era of Precision Medicine: A Review Based on HBV, MMR, HPV, and COVID-19 Vaccines
| Autor: | Nataša Karas Kuželički, Jasna Omersel |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
precision medicine lcsh:Medicine Review MMR vaccine medicine.disease_cause Measles Rubella vaccinomics 03 medical and health sciences 0302 clinical medicine medicine genetics human Papilloma virus adversomics Intensive care medicine 030304 developmental biology 0303 health sciences business.industry lcsh:R COVID-19 Rubella virus General Medicine Hepatitis B medicine.disease Precision medicine Vaccination 030220 oncology & carcinogenesis Pharmacogenomics hepatitis B business |
| Zdroj: | Journal of Clinical Medicine, Vol 9, Iss 3561, p 3561 (2020) Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm9113561 |
| Popis: | Precision medicine approaches based on pharmacogenomics are now being successfully implemented to enable physicians to predict more efficient treatments and prevention strategies for a given disease based on the genetic background of the patient. This approach has already been proposed for vaccines, but research is lagging behind the needs of society, and precision medicine is far from being implemented here. While vaccinomics concerns the effectiveness of vaccines, adversomics concerns their side effects. This area has great potential to address public concerns about vaccine safety and to promote increased public confidence, higher vaccination rates, and fewer serious adverse events in genetically predisposed individuals. The aim here is to explore the contemporary scientific literature related to the vaccinomic and adversomic aspects of the three most-controversial vaccines: those against hepatitis B, against measles, mumps, and rubella, and against human Papilloma virus. We provide detailed information on the genes that encode human leukocyte antigen, cytokines and their receptors, and transcription factors and regulators associated with the efficacy and safety of the Hepatitis B and Measles, Mumps and Rubella virus vaccines. We also investigate the future prospects of vaccinomics and adversomics of a COVID-19 vaccine, which might represent the fastest development of a vaccine ever. |
| Databáze: | OpenAIRE |
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