The influence of pre-transplant etiology of renal disease on lipoprotein lipids in female renal allograft receipients
| Autor: | Lynn K. Abbott, John A. Charlesworth, Janet M. Aitken, John B. Somer, Graham J. Macdonald |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Very low-density lipoprotein Lipoproteins Lipoproteins VLDL Gastroenterology chemistry.chemical_compound High-density lipoprotein Internal medicine medicine Humans Transplantation Homologous Kidney transplantation Cholesterol business.industry Glomerulonephritis medicine.disease Analgesic nephropathy Kidney Transplantation Transplantation Lipoproteins LDL Endocrinology chemistry Low-density lipoprotein lipids (amino acids peptides and proteins) Female Kidney Diseases Cardiology and Cardiovascular Medicine business Lipoproteins HDL |
| Zdroj: | Atherosclerosis. 37(1) |
| ISSN: | 0021-9150 |
| Popis: | Serum and lipoprotein lipids were determined in 42 female transplant recipients and compared with age-matched and serum lipid-matched normal subjects. Eight patients had glomerulonephritis as the pre-transplant etiology of renal disease, 22 had analgesic nephropathy, 6 polycystic kidneys and 6 ureteric reflux. A number of abnormalities were observed: (i) Serum triglycerides and phospholipids were elevated in all patients. Serum cholesterol levels were increased in analgesic nephropathy, polycystic kidney and ureteric reflux, but not in glomerulonephritis patients. The serum esterified/free cholesterol ratio was reduced in all patients except those with polycystic kidneys as the pre-transplant diagnosis; (ii) All VLDL lipids were raised in transplant patients regardless of etiology of renal disease prior to transplantation; (iii) LDL lipids, cholesterol, triglyceride and phospholipid were elevated in analgesic nephropathy, polycystic kidney and ureteric reflux patients, but were normal in glomerulonephritis patients: (iv) HDL cholesterol and triglycerides were elevated in all patients regardless of etiology. HDL phospholipid levels also tended to be raised, but this was significant only in glomerulonephritis patients. Lipoprotein--lipid ratio data indicated that lipoprotein--lipid composition deviated less from normal in glomerulonephritis patients than in the other patient groups. |
| Databáze: | OpenAIRE |
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