The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis
| Autor: | Kerim Gündüz, Serap Cilaker Micili, Pelin Girgin, Seda Güzeldağ, Seden Duru, Çimen Olguner, Aydın Taşdöğen, Muhammed Akkuş, Emel Altekin, Bekir Ugur Ergur, Uğur Koca |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology lcsh:Medicine Apoptosis Cell Count Kidney lcsh:Technology chemistry.chemical_compound Malondialdehyde lcsh:Science Cecum Lung General Environmental Science Caspase 3 Acute kidney injury General Medicine Acute Kidney Injury Lipocalins medicine.anatomical_structure Creatinine Dexmedetomidine medicine.drug Research Article medicine.medical_specialty Article Subject Acute Lung Injury DNA Fragmentation Lung injury General Biochemistry Genetics and Molecular Biology Sepsis Lipocalin-2 Proto-Oncogene Proteins Macrophages Alveolar medicine Animals Rats Wistar business.industry lcsh:T urogenital system lcsh:R medicine.disease Rats Mononuclear cell infiltration Disease Models Animal chemistry lcsh:Q business Acute-Phase Proteins |
| Zdroj: | The Scientific World Journal The Scientific World Journal, Vol 2013 (2013) |
| ISSN: | 1537-744X 2356-6140 |
| Popis: | In the present study, the effects of dexmedetomidine on secondary lung and kidney injuries were studied in the rat model of intra-abdominal sepsis by immunohistological and biochemical examinations. We measured serum creatinine, kidney tissue malondialdehide and plasma neutrophil gelatinase-associated lipocalin levels. In order to evaluate tissue injury we determined kidney tissue mononuclear cell infiltration score, alveolar macrophage count, histological kidney and lung injury scores and kidney and lung tissue immunoreactivity scores. We demonstrated that dexmedetomidine attenuates sepsis-induced lung and kidney injuries and apoptosis in the rat model of sepsis. There is still need for comparative studies in order to determine the effects of dexmedetomidine on organ functions in early human sepsis. |
| Databáze: | OpenAIRE |
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