Prenatal, but not early postnatal, exposure to a Western diet improves spatial memory of pigs later in life and is paired with changes in maternal prepartum blood lipid levels

Autor: Walter J. J. Gerrits, Caroline Clouard, J. Elizabeth Bolhuis, David Val-Laillet, Bas Kemp, A.C. Bartels
Přispěvatelé: Department of Animal Sciences, Adaptation Physiology Group, Wageningen University and Research [Wageningen] (WUR), Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Animal Sciences, Animal Nutrition Group, Fondation Fyssen, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Blood Glucose
Leptin
cognition
Animal Nutrition
Swine
Prenatal Programming
medicine.medical_treatment
Blood lipids
Prenatal Nutritional Physiological Phenomena
Biochemistry
Cognition
0302 clinical medicine
Pregnancy
fat
Insulin
Spatial Memory
2. Zero hunger
Diervoeding
Lipids
Cholestero
Prenatal programming programming
Adaptation Physiology
Animal Nutritional Physiological Phenomena
Female
Biotechnology
medicine.medical_specialty
Offspring
refined sugar
Biology
03 medical and health sciences
Internal medicine
Genetics
medicine
Animals
prenatal programming
Adaptatiefysiologie
Molecular Biology
cholesterol
medicine.disease
Obesity
Animal Feed
Dietary Fats
Diet
030104 developmental biology
Endocrinology
Fat
WIAS
Refined sugar
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
030217 neurology & neurosurgery
Zdroj: FASEB Journal
FASEB Journal, 2016, 30 (7), pp.2466-2475. ⟨10.1096/fj.201500208R⟩
FASEB Journal, 30(7), 2466-2475
FASEB Journal, Federation of American Society of Experimental Biology, 2016, 30 (7), pp.2466-2475. ⟨10.1096/fj.201500208R⟩
FASEB Journal 30 (2016) 7
ISSN: 0892-6638
1530-6860
DOI: 10.1096/fj.201500208R⟩
Popis: Maternal obesity and perinatal high-fat diets are known to affect cognitive development. We examined the effects of late prenatal and/or early postnatal exposure to a Western-type diet, high in both fat and refined sugar, on the cognition of pigs (Sus scrofa) in the absence of obesity. Thirty-six sows and their offspring were assigned to 1 of 4 treatments in a 2 3 2 factorial arrangement, with 8 wk prenatal and 8 wk postnatal exposure to a Western diet (enriched in fat, sucrose, and cholesterol) or control diets as factors. Compared to controls, piglets exposed to the prenatal Western diet showed enhanced working and reference memory during the acquisition and reversal phases of a spatial hole-board task. Mothers fed the prenatal Western diet had higher prepartum blood cholesterol and free fatty acid levels. Postnatal exposure to the Western diet did not affect piglet cognitive performance, but it did increase postpartum maternal and postweaning piglet cholesterol levels. The Western diet had no effect on maternal or offspring insulin sensitivity or leptin levels. In conclusion, a prenatal Western diet improved memory function in pigs, which was paired with changes in prepartum maternal blood cholesterol levels. These findings highlight the key role of late fetal nutrition for long-term programming of cognition.-Clouard, C., Kemp, B., Val-Laillet, D., Gerrits, W. J. J., Bartels, A. C., Bolhuis, J. E. Prenatal, but not early postnatal, exposure to a Western diet improves spatial memory of pigs later in life and is paired with changes in maternal prepartum blood lipid levels.
Databáze: OpenAIRE
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