Effect of physical training on exercise capacity, gas exchange and N-terminal pro-brain natriuretic peptide levels in patients with chronic heart failure
| Autor: | Pietro Di Pasquale, Antonio Castello, Gesualdo Serio, Tommaso Gristina, Raffaella Raimondi, Salvatore Milia, Massimo Sajeva, Salvatore Paterna, Ignazio Brusca, Stella Maria La Chiusa, Filippo M. Sarullo |
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| Přispěvatelé: | FSARULLO, GRISTINA T, BRUSCA I, MILIA S, RAIMONDI R, SAJEVA M, LA CHIUSA S, SERIO G, PATERNA S, DI PASQUALE P, CASTELLO A |
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Epidemiology medicine.drug_class Internal medicine Natriuretic Peptide Brain Natriuretic peptide Medicine Humans In patient Exercise physiology congestive heart failure exercise capacity gas exchange N-terminal pro-brain natriuretic peptide physical training Exercise Heart Failure Ejection fraction business.industry Pulmonary Gas Exchange Exercise capacity Middle Aged Brain natriuretic peptide medicine.disease Peptide Fragments Physical Fitness Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business N-terminal pro-Brain Natriuretic Peptide |
| Zdroj: | European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on EpidemiologyPrevention and Cardiac Rehabilitation and Exercise Physiology. 13(5) |
| ISSN: | 1741-8267 |
| Popis: | BACKGROUND: Decreased exercise capacity is the main factor restricting the daily life of patients with chronic heart failure. N-terminal pro-brain natriuretic peptide (NT pro-BNP) is strongly related to the severity of and is an independent predictor of outcome in chronic heart failure. DESIGN: The study aimed to evaluate the effect of exercise training on functional capacity and on changes in NT pro-BNP levels and to assess the effect of exercise training on quality of life. MATERIALS AND METHODS: Sixty patients (45 men/15 women, mean age 52.7 years; +/-5.3 SD), with stable heart failure (45 ischaemic/hypertensive and 15 idiopathic patients), in New York Heart Association (NYHA) functional class II (n=35) to III (n=25), with an ejection fraction less than 40%, were randomly assigned to a training (n=30) and a control group (n=30). The training group (30 patients) performed 3 months of supervised physical training programme using a bicycle ergometer for 30 min three times a week at a load corresponding to 60-70% of their oxygen consumption (VO2) peak. The control group did not change their previous physical activity. A graded maximal exercise test with respiratory gas analysis and an endurance test with constant workload corresponding to 85% of the peak oxygen load at the baseline and after 3 months were performed, and at the same times NT pro-BNP levels were measured. RESULTS: The exercise capacity increased from 15.8 (+/-2.3 SD) to 29.9 (+/-2.1 SD) min (P |
| Databáze: | OpenAIRE |
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