Human beta-defensin-1 rs2738047 polymorphism is associated with shisha smoking risk among Saudi population
| Autor: | Mohammad Alanazi, Abdelhabib Semlali, Abdulwahed F. Alrefaei, Bader Almutairi, Narasimha Reddy Parine, Mikhlid Almutairi, Mohammad Almutairi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Genotyping beta-Defensins Genotype Health Toxicology and Mutagenesis Population Saudi Arabia 010501 environmental sciences 01 natural sciences Polymorphism Single Nucleotide Smoking Water Pipes Saudi Polymorphism (computer science) medicine Environmental Chemistry SNP Humans Respiratory system Allele Polymorphism education 0105 earth and related environmental sciences Asthma education.field_of_study business.industry Smoking General Medicine medicine.disease Pollution rs2738047 Human β-defensin-1 Immunology Female business Research Article |
| Zdroj: | Environmental Science and Pollution Research International |
| ISSN: | 1614-7499 0944-1344 |
| Popis: | Human β-defensin (HBD), a member of the antimicrobial peptides, is essential for respiratory epithelial cells’ microbial defense, and is affected by cigarette smoking (CS). Its expression is upregulated by stimulation from microbes or inflammation. Genetic polymorphisms in the HBD-1 gene have been implicated in the development of various smoking-related diseases, including chronic obstructive pulmonary disease and asthma. Thus, we sought to analyze possible associations between HBD-1 single-nucleotide polymorphism (SNP) in HBD-1 gene and CS in ethnic Saudi Arabian subjects. Variants rs1047031 (C/T), rs1799946 (C/T), rs2738047 (C/T), and rs11362 (C/T) were investigated by genotyping 575 blood specimens from males and females, smokers/non-smokers: 288/287. The CT and CT+TT genotypes of rs1799946 presented an ~5-fold increased correlation with CS among the female smokers, compared with the female controls (OR = 5.473, P = 0.02003; and OR = 5.211, P = 0.02028, respectively), an observation similar to rs11362 SNP in female smokers, but with protective effects in TT genotype, compared with the CC reference allele (OR = 0.143, P = 0.04368). In shisha smokers, the heterozygous CT and the CT/TT genotype of rs2738047 polymorphism showed the same results with ~3-fold increased correlation with CS (OR = 2.788; P = 0.03448), compared with the cigarette smokers category. No significant association was shown in genotypic distributions and allelic frequencies of rs1047031. Further investigations, including large study samples, are required to investigate the effects of shisha on human beta-defensin expression and protein levels. |
| Databáze: | OpenAIRE |
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