A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma
| Autor: | Juan Pablo Castanedo-Cazares, Liliana Elizabeth Espinal-Perez, Benjamin Moncada |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Vitamin medicine.medical_specialty Randomization Combination therapy Melasma Administration Topical Ascorbic Acid Dermatology Melanosis law.invention chemistry.chemical_compound Double-Blind Method Randomized controlled trial law medicine Humans Hydroquinone business.industry medicine.disease Ascorbic acid Hyperpigmentation Hydroquinones Surgery Treatment Outcome chemistry Female Dermatologic Agents medicine.symptom business |
| Zdroj: | International Journal of Dermatology. 43:604-607 |
| ISSN: | 1365-4632 0011-9059 |
| DOI: | 10.1111/j.1365-4632.2004.02134.x |
| Popis: | Background Melasma is an acquired treatment-resistant hyperpigmentation of the skin. Methods Sixteen women with idiopathic melasma were included in our trial. After randomization by another clinician, they were instructed to use, at night, 5% ascorbic acid cream on one side of the face and 4% hydroquinone cream on the other side, for 16 weeks. Sunscreen was applied daily throughout the period of observation. They were evaluated every month by colorimetry, digital photography, and regular color slides. Subjective evaluation by each patient was also taken into account. Results The best subjective improvement was observed on the hydroquinone side with 93% good and excellent results, compared with 62.5% on the ascorbic acid side (P |
| Databáze: | OpenAIRE |
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