Secondary metabolites and their biological activities in Indonesian soft coral of the genus Lobophytum
| Autor: | Annissa Nur Cahya Saputri, Meilia Rahma Widhiana, Irma S. Arlyza, Joko Tri Wibowo, Masteria Yunovilsa Putra, Tutik Murniasih, Respati Tri Swasono |
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| Rok vydání: | 2016 |
| Předmět: |
Ocean
lcsh:Arctic medicine. Tropical medicine Antioxidant food.ingredient lcsh:RC955-962 medicine.medical_treatment Ethyl acetate Brine shrimp 01 natural sciences Biochemistry Genetics and Molecular Biology (miscellaneous) Lobophytum chemistry.chemical_compound food medicine Bioassay Cytotoxicity lcsh:QH301-705.5 Heme Natural products Chromatography biology 010405 organic chemistry Chemistry Butanol Biological activities biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry lcsh:Biology (General) Biochemistry Indonesia |
| Zdroj: | Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 11, Pp 909-913 (2016) |
| ISSN: | 2221-1691 |
| DOI: | 10.1016/j.apjtb.2016.08.011 |
| Popis: | Objective To investigate the antioxidant, antibacterial, antimalarial activities and cytotoxicity of the n -hexane, ethyl acetate, n -butanol, and aqueous fractions from a crude extract of Lobophytum sp. Methods This organism was collected from the Selayar Islands (South Sulawesi). The antioxidant activity was performed by the 1,1-diphenyl-2-picryl hydrazyl radical scavenging method. All fractions from the crude extract of Lobophytum sp. were examined for their cytotoxicity using the brine shrimp lethality bioassay and heme polymerization inhibitory activity assay for antimalarial activity. Results It was found that the ethyl acetate, n -butanol and aqueous fractions exhibited heme polymerization inhibitory activity with IC 50 values of 11.7, 14.3 and 12.0 μg/mL, respectively, while the n -butanol fraction showed moderate antioxidant activity and cytotoxicity with IC 50 values of 150.00 and 92.74 μg/mL, respectively. Conclusions This study provides information on antioxidant, antibacterial and antimalarial activities as well as the cytotoxicity of all fractions from the crude extract of Lobophytum sp. This is a new report of antimalarial substances derived from Lobophytum sp. |
| Databáze: | OpenAIRE |
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