Developmental changes in the chemosensitivity of rat brain synaptoneurosomes to excitatory amino acids, estimated by inositol phosphate formation

Autor: Isabelle Sassetti, Max Récasens, Janique Guiramand
Přispěvatelé: Neurobiologie de l'audition-plasticité synaptique, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)
Jazyk: angličtina
Rok vydání: 1989
Předmět:
Male
Aging
Synaptogenesis
MESH: Frontal Lobe
MESH: Sugar Phosphates
MESH: Aspartic Acid
Norepinephrine
chemistry.chemical_compound
0302 clinical medicine
Glutamates
Muscarinic acetylcholine receptor
Inositol
MESH: Aging
MESH: Animals
Inositol phosphate
Synaptoneurosomes
chemistry.chemical_classification
Synaptosome
Oxadiazoles
0303 health sciences
Muscarinic receptor
MESH: Glutamic Acid
Brain development
Inositol phosphate formation
Frontal Lobe
MESH: N-Methylaspartate
MESH: Synaptosomes
Excitatory postsynaptic potential
NMDA receptor
Female
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
medicine.drug
medicine.medical_specialty
N-Methylaspartate
Carbachol
MESH: Rats
Inositol Phosphates
Glutamic Acid
Biology
Quisqualate N-methyl-D-aspa~ate
03 medical and health sciences
MESH: Glutamates
Developmental Neuroscience
Internal medicine
MESH: Norepinephrine
medicine
Animals
030304 developmental biology
Aspartic Acid
MESH: Quisqualic Acid
MESH: Oxadiazoles
Quisqualic Acid
MESH: Inositol Phosphates
MESH: Male
Rats
MESH: Carbachol
Endocrinology
chemistry
Excitatory amino acid receptor
Potassium
Sugar Phosphates
MESH: Female
030217 neurology & neurosurgery
Synaptosomes
Developmental Biology
Zdroj: International Journal of Developmental Neuroscience
International Journal of Developmental Neuroscience, Elsevier, 1989, 7 (3), pp.257-66. ⟨10.1016/0736-5748(89)90030-0⟩
ISSN: 0736-5748
DOI: 10.1016/0736-5748(89)90030-0⟩
Popis: International audience; The evolution of excitatory amino acids-(EAA) stimulated inositol phosphates (IPs) turnover during postnatal development was investigated in synaptoneurosomes prepared from rat forebrains. The two main EAA agonists which induce the IPs synthesis were quisqualate (QA) and N-methyl-D-aspartate (NMDA). The QA and NMDA stimulations of IPs formation present a particular developmental pattern, characterized by an active phase during rat synaptogenesis. The QA-evoked IPs accumulation peaked in synaptoneurosomes prepared from 8-day-old rat forebrains while that evoked by NMDA peaked in synaptoneurosomes from 12-day-old rats. These two developmental patterns are specific of the EAA agonists since the other various neuroactive substances tested (carbachol (Carb), noradrenaline, and high concentrations of potassium) induced an IPs accumulation, which increases during development and reaches a maximum in synaptoneurosomes of adult animals. Aging leads to a decrease in the capability of EAAs and muscarinic agonists to stimulate IPs formation in synaptoneurosomes, whereas the stimulation of IPs turnover by noradrenaline remains constant. Taken together, these results suggest that EAAs play a key role during brain development by sequentially activating two receptor subtypes, a new QA receptor, and a NMDA receptor, linked to the phosphoinositide metabolism. They may also indicate that these EAA-induced IPs responses are related to neuronal plastic events, the amplitude of which decreases with aging.
Databáze: OpenAIRE
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