Prior Anticoagulation in Patients with Ischemic Stroke and Atrial Fibrillation
| Autor: | Davide Strambo, Giovanni Bianco, Timo Kahles, Ludwig Schelosky, Mira Katan, Elisabeth Dirren, Christian Berger, David J. Seiffge, Roland Backhaus, Marcel Arnold, Mattia Branca, Patrik Michel, Julien Niederhäuser, Carlo W. Cereda, Stefan T. Engelter, Marie-Luise Mono, Emmanuel Carrera, Georg Kägi, Susanne Renaud, Urs Fischer, Christophe Bonvin, Biljana Rodic, Johannes Kaesmacher, Sylvan Albert, Krassen Nedeltchev, Gian Marco De Marchis, Pasquale Mordasini, Friedrich Medlin, Mirjam Rachel Heldner, Leo H. Bonati, Simon Jung, Stephan Salmen, Manuel Bolognese, Michael Schaerer, Alexander A. Tarnutzer, Jan Gralla, Thomas Raphael Meinel, Jochen Vehoff |
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| Přispěvatelé: | Investigators of the Swiss Stroke Registry, Lyrer, P., Peters, N., Polymeris, A., Thilemann, S., Altersberger, V., Blackham, K., Dittrich, T., El Mekabaty, A., Fladt, J., Fisch, U., Gensicke, H., Hert, L., Manuzzi, S., Psychogios, M., Maurer, M., Traenka, C., Tsogkas, I., Wagner, B., Zietz, A., Brehm, A., Meya, L., Sarikaya, H., Goeldlin, M., Vynckier, J., Mamaari, B., Siepen, B., Mueller, M., Eskandari, A., Pantazou, V., Wegener, S., Mueller, A., Schütz, V., Pokorny, T., Luft, A., Albert, S., Sturzenegger, R., Humm, A., Cuendet, D., Accolla, E., Annoni, J.M., Foucras, S., Minkner, K.K., Olivier, P., Kelemen, P., Brodo, G., Cordier, M., Jurgutiene, V., Sotomayor, G.T., Fisch, L. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment 610 Medicine & health macromolecular substances Anticoagulants Anticoagulation DOAC Ischaemic Stroke Thrombectomy Thrombolysis Brain Ischemia 03 medical and health sciences 0302 clinical medicine Modified Rankin Scale Interquartile range Internal medicine Atrial Fibrillation medicine cardiovascular diseases Research Articles Ischemic Stroke business.industry Confounding Atrial fibrillation Odds ratio medicine.disease Confidence interval ddc:616.8 030104 developmental biology Neurology Cardiology Neurology (clinical) business 030217 neurology & neurosurgery Research Article Cohort study |
| Zdroj: | Annals of neurology, vol. 89, no. 1, pp. 42-53 Meinel, Thomas R.; Branca, Mattia; De Marchis, Gian Marco; Nedeltchev, Krassen; Kahles, Timo; Bonati, Leo; Arnold, Marcel; Heldner, Mirjam R.; Jung, Simon; Carrera, Emmanuel; Dirren, Elisabeth; Michel, Patrik; Strambo, Davide; Cereda, Carlo W; Bianco, Giovanni; Kägi, Georg; Vehoff, Jochen; Katan, Mira; Bolognese, Manuel; Backhaus, Roland; ... (2021). Prior anticoagulation in patients with ischaemic stroke and atrial fibrillation. Annals of neurology, 89(1), pp. 42-53. Wiley-Blackwell 10.1002/ana.25917 Annals of Neurology, Vol. 89, No 1 (2021) pp. 42-53 Annals of Neurology |
| ISSN: | 0364-5134 |
| Popis: | OBJECTIVE The aim was to evaluate, in patients with atrial fibrillation (AF) and acute ischemic stroke, the association of prior anticoagulation with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) with stroke severity, utilization of intravenous thrombolysis (IVT), safety of IVT, and 3-month outcomes. METHODS This was a cohort study of consecutive patients (2014-2019) on anticoagulation versus those without (controls) with regard to stroke severity, rates of IVT/mechanical thrombectomy, symptomatic intracranial hemorrhage (sICH), and favorable outcome (modified Rankin Scale score 0-2) at 3 months. RESULTS Of 8,179 patients (mean [SD] age, 79.8 [9.6] years; 49% women), 1,486 (18%) were on VKA treatment, 1,634 (20%) on DOAC treatment at stroke onset, and 5,059 controls. Stroke severity was lower in patients on DOACs (median National Institutes of Health Stroke Scale 4, [interquartile range 2-11]) compared with VKA (6, [2-14]) and controls (7, [3-15], p |
| Databáze: | OpenAIRE |
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