Baseline MRI associates with later naming status in primary progressive aphasia
Autor: | Donna C. Tippett, Argye E. Hillis, Andreia V. Faria, Aaron M. Meyer, Rhonda B. Friedman |
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Rok vydání: | 2020 |
Předmět: |
Male
Linguistics and Language medicine.medical_specialty Cognitive Neuroscience Experimental and Cognitive Psychology Disease Audiology Article 050105 experimental psychology Language and Linguistics Primary progressive aphasia 03 medical and health sciences Speech and Hearing 0302 clinical medicine Connectome medicine Humans 0501 psychology and cognitive sciences Baseline (configuration management) Aged Multimodal imaging medicine.diagnostic_test Resting state fMRI Extramural Functional connectivity 05 social sciences Brain Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Aphasia Primary Progressive Female Psychology 030217 neurology & neurosurgery |
Zdroj: | Brain Lang |
ISSN: | 0093-934X |
Popis: | Advanced imaging studies in neurodegenerative disease have yielded new insights into subtypes of disease, progression of disease in various brain regions, and changes in structural and functional connectivity between brain regions related to symptom progression. However, few studies have revealed imaging markers at baseline that correlate with rate or degree of decline in function. Here we tested the hypothesis that imaging features at baseline correlate with outcome of naming in primary progressive aphasia. We obtained longitudinal multimodal imaging in 15 individuals with primary progressive aphasia at the same time points as assessment of naming. We found that functional connectivity between particular brain regions (measured with resting state functional connectivity magnetic resonance imaging) is strongly associated with accuracy of naming 21 months later, independently of baseline severity of naming impairment. These data indicate that functional connectivity may carry information about later performance in naming, and is potentially useful for refining prognosis. |
Databáze: | OpenAIRE |
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